ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1600097
TyG Index and CBC-Derived Inflammatory Indicators Individual and Mixed Effects on All-Cause and Cardiovascular Disease Deaths in Patients with CHD
Provisionally accepted
- 1Huizhou Third Peoole's Hospital, Huizhou, China
- 2Huizhou Affiliated Hospital of Sun Yat-sen University, Huizhou, Guangdong Province, China
- 3Guoyao North Hospital, Baotou, China
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Background and Aims: Most epidemiological studies focus on single indicators for cardiovascular disease (CVD) risk, yet individual markers often inadequately reflect patient health. A comprehensive assessment using multiple indicators is crucial. The Triglyceride-Glucose (TyG) index and Complete Blood Count (CBC)-derived inflammatory markers are gaining attention, but research on their individual and combined impact on all-cause and cardiovascular mortality risk in coronary heart disease (CHD) patients is limited. This study aimed to develop a more accurate clinical risk assessment tool for coronary artery disease (CAD) management. Methods and Results: CHD patients aged ≥20 years were identified from five NHANES cycles (2009-2018). Weighted logistic regression and restricted cubic spline (RCS) analyses assessed the TyG index and CBC-derived inflammatory markers (SII, SIRI, MLR, NLR, PLR) for association with all-cause and cardiovascular mortality. A Weighted Quantile Sum (WQS) model estimated their cumulative exposure effect. In unadjusted models, ln(SII), ln(SIRI), ln(MLR), ln(NLR), and ln(PLR) were positively associated with all-cause mortality risk (all p<0.05, ORs ranging 1.8-2.57). After full confounder adjustment, these associations remained significant. RCS analysis showed nonlinear dose-response relationships between MLR, NLR, PLR, SII, SIRI, and all-cause mortality (P-nonlinear <0.05). The WQS model indicated that combined exposure to the TyG index and CBC inflammatory markers significantly increased risks for all-cause mortality (OR=1.68, 95% CI=1.22-2.30, P=0.009) and cardiovascular death (OR=2.2, 95% CI=1.42-3.42, P=0.0004) in CAD patients, with NPR and SII contributing most substantially to the overall risk. Conclusion: The TyG index and CBC-derived inflammatory indices are significant risk factors for all-cause and cardiovascular mortality in CHD patients, with NPR and SII representing the largest contributors within these factors.
Keywords: TyG index, CBC Inflammatory Marker, All-cause mortality, cardiovascularmortality, Environmental Health, CBC-derived inflammatory index, CHD, cardiovasculardisease mortality
Received: 26 Mar 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 蔡, Yan, Sun and Dan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: 立鹏 蔡, Huizhou Third Peoole's Hospital, Huizhou, China
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