ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1604270
This article is part of the Research TopicAddressing insulin resistance and hyperinsulinemia for cardiovascular disease preventionView all 12 articles
The nonlinear association between the triglyceride glucose-waist-to-height ratio index and cardiovascular disease among middle-aged and older adults in China with cardiovascular-kidney-metabolic syndrome stages 0-3
Provisionally accepted
- The First people's Hospital of Xiaoshan District, Hangzhou, China
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Background Cardiovascular disease (CVD) poses a critical challenge to global public health, especially in individuals with Cardiovascular-Kidney-Metabolic (CKM) syndrome. The association between the triglyceride glucose-waist-to-height ratio index (TyG-WHtR) and CVD among middle-aged and older Chinese adults with CKM stages 0-3 is not well understood. Methods Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative longitudinal study of individuals aged 45 years and older. Cox proportional hazards models were constructed to evaluate the association between TyG-WHtR and CVD risk. Subgroup analyses were conducted among different groups to evaluate consistency of findings and explore potential interactions. Restricted cubic spline regression was employed to evaluate the dose-response relationship. Results During a mean follow-up period of 7.77 ± 2.13 years, 1,595 participants (23.58%) developed CVD. After adjusting for covariates, TyG-WHtR was significantly associated with CVD risk (HR: 1.09, 95% CI: 1.01–1.18). Notably, this relationship was independent of other variables and displayed a nonlinear pattern, with an inflection point identified at 3.57. Beyond this threshold, the adjusted HR increased to 1.17 (95%CI: 1.08-1.71). Conclusion TyG-WHtR demonstrates a nonlinear relationship with CVD among middle-aged and older Chinese adults with CKM stages 0-3.
Keywords: TyG-WHtR, cardiovascular disease, cardiovascular-kidney-metabolic syndrome, Chinese, CHARLS
Received: 01 Apr 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Huang, Jia and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Cheng Huang, The First people's Hospital of Xiaoshan District, Hangzhou, China
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