REVIEW article
Front. Cardiovasc. Med.
Sec. Atherosclerosis and Vascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1606034
This article is part of the Research TopicCardiovascular calcification: disease mechanisms, clinical phenotypes and therapeutic strategiesView all 7 articles
The Role of Interferon Regulatory Factors in Atherosclerosis
Provisionally accepted
- 1Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China
- 2Department of Health Science Center, Ningbo University, Ningbo, Zhejiang, China
- 3Department of Cardiology, Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, Ningbo, China
- 4Clinical Medicine Research Centre for Cardiovascular Disease of Ningbo, Ningbo, China
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Cardiovascular diseases(CVDs) remain a leading cause of global morbidity and mortality, largely driven by the progression of atherosclerotic plaques. In atherosclerosis (AS), transcription factors and epigenetic mechanisms play pivotal roles in regulating gene expression. Interferon regulatory factors (IRFs), a family of transcription factors initially identified for their role in coordinating interferon (IFN) responses, are now recognized as critical modulators of innate and adaptive immunity. Emerging evidences highlights their involvement in inflammation, lipid metabolism, cell differentiation, cell proliferation, and programmed cell death during AS pathogenesis. This review synthesizes current knowledge on the roles and regulatory mechanisms of IRFs in AS, offering novel insights and potential therapeutic targets for AS management.
Keywords: Interferon Regulatory Factors, Atherosclerosis, Inflammation, Lipid Metabolism, Cell Death
Received: 04 Apr 2025; Accepted: 14 Aug 2025.
Copyright: © 2025 Wang, fang, Zheng and Huangfu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ning Huangfu, Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China
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