ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Intensive Care Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1609295
This article is part of the Research TopicTherapies Approaches in Venous Thromboembolism Management and CoagulationView all 11 articles
Lactate to albumin ratio as a prognostic marker for all-cause mortality in patients with venous thromboembolism: A retrospective cohort study
Provisionally accepted
- First People's Hospital of Foshan, Foshan, China
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Background: The lactate to albumin ratio (LAR) may serve as a prognostic marker. This study evaluated its association with clinical outcomes in patients with venous thromboembolism (VTE). Methods: We performed a retrospective cohort analysis using data from the MIMIC-IV 3.1 database, including 4,181 patients diagnosed with VTE. The primary outcomes were 30-day and 365-day all-cause mortality. Cox proportional hazards models assessed the relationship between LAR and mortality. Restricted cubic spline (RCS) analysis examined the non-linear relationship. Kaplan-Meier (KM) survival curves were generated to compare outcomes across the LAR groups. Results: Among the 1,992 patients included in the study, mortality rates at 30 and 365 days were 19.58% and 22.69%, respectively. Elevated LAR levels were significantly associated with increased mortality at both time points (P < 0.001). The hazard ratio (HR) for 30-day mortality was 2.02 (95% CI: 1.42–2.88), while for 365-day mortality, it was 1.83 (95% CI: 1.33–2.52). Receiver operating characteristic (ROC) analysis demonstrated that LAR+SOFA had an area under the curve (AUC) of 0.670 for 30-day mortality and 0.664 for 365-day mortality. Subgroup and sensitivity analyses confirmed the robustness of these findings across different clinical scenarios. Conclusions: Elevated LAR is significantly associated with increased mortality in VTE patients.LAR can be used as a potential indicator for assessing the short-and long-term risk of mortality in such patients.
Keywords: lactate to albumin ratio, Venous Thromboembolism, MIMIC-IV database, Mortality, Retrospective cohort study
Received: 16 Apr 2025; Accepted: 17 Sep 2025.
Copyright: © 2025 Huang, Zhang, Mei, Li, Wu and Xiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xia Xiang, xiangxiafoshan@163.com
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