ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1609672
This article is part of the Research TopicEnvironmental Determinants of Cardiovascular Health: Interactions with Lifestyle and Socioeconomic FactorsView all 8 articles
The burden of atherosclerotic cardiovascular disease among working-age people across SDI regions: An Age-Period-Cohort Study Based on the GBD 2021
Provisionally accepted
- 1School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
- 2Department of Intensive Care Unit, The Second Hospital of Nanjing, Affliated of Nanjing University of Chinese Medicine, Nanjing,China, Nanjing, China
- 3Chongqing prevention and treatment center for occupational diseases, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing 400060, China, Chongqing, China
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Atherosclerotic cardiovascular disease (ASCVD) remains a leading health threat to the working-age population globally, with marked disparities in incidence and mortality across countries at different levels of socio-demographic development.Based on data from the Global Burden of Disease Study 2021, we used an age-periodcohort (APC) model to evaluate trends in the incidence and mortality of three major ASCVD subtypes-ischemic heart disease (IHD), ischemic stroke (IS), and peripheral artery disease (PAD)-among working-age adults (15-64 years) from 1992 to 2021 across five socio-demographic index (SDI) regions. The model further explored the contributions of age, period, and cohort effects.Although age-standardized incidence and mortality rates of ASCVD have declined in most high-SDI regions and globally, the absolute number of cases and deaths has continued to rise, especially in middle-and low-SDI regions. Notably, PAD showed increasing incidence trends in several developing regions, suggesting persistent gaps in public awareness and preventive efforts.ASCVD remains a significant global public health challenge among the working-age population. SDI-specific and accessible interventions, along with strengthened crosssector collaboration, are urgently needed to promote effective prevention and control of ASCVD worldwide.
Keywords: Atherosclerotic cardiovascular disease₁, Working-age population₂, age-period-cohort analysis3, Global Burden of Disease4, Socio-demographic Index₅, Ischemic heart disease₆, ischemic stroke7, Peripheral artery disease₈
Received: 10 Apr 2025; Accepted: 15 Aug 2025.
Copyright: © 2025 Yan, Xie, Wu, Tang and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yong-Gang Tang, Chongqing prevention and treatment center for occupational diseases, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing 400060, China, Chongqing, China
Yang-Guang Yin, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu Province, China
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