ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1609798
This article is part of the Research TopicMolecular Biomarkers of Cardiometabolic Disease - Volume IIView all 14 articles
Evaluation of the prognosis of elderly patients with heart failure by Monocyte-to-High-Density Lipoprotein Ratio (MHR), Neutrophil Gelatinase-Associated Lipocalin (NGAL), and Angiotensin II (Ang II)
Provisionally accepted
- 1Beijing Aerospace General Hospital, Beijing, China
- 2Beijing Emergency General Hospital, Beijing, China
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Objective: The objective of this research was to investigate the correlation between the Monocyte-to-high-density lipoprotein-cholesterol ratio (MHR), Neutrophil gelatinase-associated lipocalin (NGAL), and Angiotensin II (Ang II) with both short-term and long-term mortality rates in elderly patients with heart failure (HF).Methods: A retrospective cohort study was conducted, encompassing elderly HF patients hospitalized from 2020 to 2023. Multivariable logistic regression analysis was employed to assess the relationship between MHR, NGAL, Ang II, and mortality risk.Results: The predictive power of these biomarkers for mortality in patients with HF was determined using the area under the receiver operating characteristic curve (AUC). Each of the biomarkers—MHR, NGAL, and Ang II—was linked to an increased risk of mortality at one month (OR =1.007, 95% CI: 1.003–1.012), (OR =1.004, 95% CI: 1.001–1.007), (OR =1.002, 95% CI: 1.001–1.004) and at one year (OR = 1.007, 95% CI: 1.002–1.011), (OR = 1.004, 95% CI: 1.001–1.008), (OR = 1.003, 95% CI: 1.001–1.006) in the elderly patients with HF. The AUC for MHR, NGAL, and Ang II in forecasting one-month mortality were 0.740 (95% CI: 0.668-0.811), 0.659 (95% CI: 0.581-0.738), and 0.628 (95% CI: 0.547-0.710), respectively. For one-year mortality, the AUC values were 0.728 (95% CI: 0.655-0.800), 0.641 (95% CI: 0.560-0.721), and 0.627 (95% CI: 0.546-0.708), respectively. The optimal thresholds for MHR, NGAL, and Ang II in predicting one-month mortality were identified as 0.52, 85 ng/mL, and 25 pg/mL, respectively, while for one-year mortality, the thresholds were 0.50, 70 ng/mL, and 24 pg/mL, respectively.Conclusions: MHR, NGAL, and Ang II emerge as promising indicators for mortality prediction in HF patients. Among these, MHR stands out as potentially the most reliable predictor of mortality in the elderly with HF.
Keywords: MHR, NGAL, Heart Failure, prognosis, Ang
Received: 11 Apr 2025; Accepted: 27 May 2025.
Copyright: © 2025 Liu, Gan, Fu, Liu, Wang, Yang and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huadong Liu, Beijing Aerospace General Hospital, Beijing, China
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