ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Structural Interventional Cardiology
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1612869
Anatomic Rupture Location, Leukocyte Levels And Diabetes Mellitus As Factors Influencing In-Hospital Mortality Following Percutaneous Repair Of Post-Infarction Ventricular Septal Rupture: A Single Centre Study
Provisionally accepted
- 1Department of Cardiology and Vascular Medicine, Haji Adam Malik General Hospital, Universitas Sumatera Utara, Medan, Indonesia
- 2Faculty of Medicine, University of North Sumatra, Medan, Indonesia
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Post-infarction ventricular septal rupture (PIVSR) carries high mortality despite therapeutic advances. This study evaluates outcomes and mortality predictors in 22 PIVSR patients treated at H. Adam Malik Hospital, Medan, where percutaneous closure has become preferred due to surgical limitations. Methods: This single-center, retrospective cohort study analyzed 22 consecutive patients with post-infarction ventricular rupture (January 2022-May 2025), stratified by closure eligibility (n=11 per group). Comparative analyses used independent t -tests (normal data), Mann-Whitney-U tests (non-normal), and Fisher's exact tests (categorical variables). Survival analysis employed Kaplan-Meier curves with log-rank testing. Effect sizes (mean differences, risk differences, odds ratios) are reported with 95% confidence intervals. Results: The non-closure group had higher leukocyte counts (14.9 ± 5.9 vs. 11.0 ± 4.0 ×10⁹/L, mean difference −3.9 [95% CI, −7.6 to −0.1] ×10⁹/L; P=0.045), greater diabetes prevalence (54.5% vs. 9.1%; risk difference −45% [−75 to −16]; P=0.032), and shorter pre-closure survival (Mean 6 ± 5 days vs. 9 ± 6 days; P<0.001). Among closure patients, apical rupture predicted universal mortality (7/7 deaths vs. 0/4 with mid-ventricular ruptures; risk difference 75% [25–100]; P=0.024), while LVEF (P=0.92) and complexity (P=1.000) showed no association. Survival favored closure (log-rank P<0.001). Conclusion: Percutaneous PIVSR closure improved survival, but outcomes depended on anatomic rupture location, with apical rupture exhibiting prevalent mortality in the closure group. Non-closure patients had shorter survival, higher leukocytes, and diabetes. While rupture location and systemic factors influenced results, further research is needed to explain these associations and optimize patient selection.
Keywords: Post-Infarction Ventricular Septal Rupture (PIVSR), Percutaneous closure, mortality factors, in-hospital outcomes, long-term follow-up, Risk factors, Single center study, Indonesia
Received: 16 Apr 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Habib, Fitri, Ardini and Nasution. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nadya Keumala Fitri, nadyafitri520@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.