REVIEW article
Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1616332
This article is part of the Research TopicAdvancing Vascular Health: A Comprehensive Framework for Non-Traditional Risk AssessmentView all 5 articles
Coronary Microvascular Dysfunction: A Review of Its Association with Extracardiac Organ Pathologies
Provisionally accepted
- The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China
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Coronary microvascular dysfunction (CMD) is a high-risk factor for numerous cardiovascular events, and there is an increasing focus on the diagnosis and treatment of CMD itself or its association with cardiovascular diseases. However, some evidences suggest potential associations between CMD and multiple extracardiac pathologies, such as cerebrovascular, renal, pulmonary, retinal, hepatic, immune system diseases, and cancer. A shared pathological mechanism may underlie these connections, yet the relationship between CMD and other organs and systemic diseases remains unclear. Therefore, this review comprehensively assesses the current evidence base for the interplay between CMD and a range of systemic diseases, highlighting the need for a more integrated diagnostic and therapeutic approach.
Keywords: Coronary microvascular dysfunction, microvascular dysfunction, non-obstructive coronary artery disease, Cardiovascular Diseases, Myocardial Ischemia
Received: 22 Apr 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Yuting, Liu, Wang, Luan, Zhou, 崔, Wang, 徐, Hu and Mao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Duan Yuting, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong Province, China
Song Hu, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong Province, China
Yongjun Mao, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong Province, China
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