REVIEW article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1618242
Coronary Microcirculatory Dysfunction After Percutaneous Coronary Intervention: Pathogenesis, Diagnosis, and Therapeutic Strategies
Provisionally accepted
- 1Henan University of Chinese Medicine, Zhengzhou, China
- 2First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
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Coronary microvascular dysfunction (CMD) can lead to a variety of severe adverse cardiovascular events. CMD represents the primary cause of recurrent angina pectoris following percutaneous coronary intervention (PCI). The etiology of post-PCI CMD is complex and largely occult, which significantly impairs the therapeutic efficacy of PCI. This article reviews the physiological functions of the coronary microcirculation, as well as the latest research progress on the pathogenesis, diagnosis, and treatment of CMD after PCI. Finally, it highlights the scientific issues that urgently need to be addressed regarding CMD after PCI and proposes future research directions, with the aim of providing forward-looking insights for the prevention and treatment of CMD after PCI in the future.
Keywords: coronary microcirculation disorder, Percutaneous coronary intervention therapy, Oxidative Stress, Inflammation, Diagnosis and treatment
Received: 25 Apr 2025; Accepted: 17 Oct 2025.
Copyright: © 2025 Jin, Wang, Hua, Han and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: YuShan Chen, rain1363371126@126.com
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