The Outcome of Possible Events Following the Hospital Discharge Of Patients With HFmrEF After MI As Compared To Those With HFmrEF Without MI: A Propensity Score-Matched Analysis (PSMA)

Zhican LiuLingling ZhangJianping Zeng^*Ming Yan Jiang^*

• Xiangtan Central Hospital, Xiangtan, China

BACKGROUND :Clinical studies reporting heart failure with mildly reduced left ventricular ejection fraction (HFmrEF) are gradually increasing. However, there are relatively few studies reported on patients with HFmrEF after myocardial infarction (MI) and the prognosis of such patients is still unclear. Therefore, we conducted a retrospective evaluation of HFmrEF patients with/without MI using a propensity score-matched analysis (PSMA). METHODS:This study included a total of 1691 patients with HFmrEF. Of these, 873 patients had a diagnosis of myocardial infarction, and 818 patients had not been diagnosed with myocardial infarction. After propensity score matching, we used Kaplan–Meier analysis and Cox regression to compare all-cause mortality, cardiovascular death or heart failure readmission(CV events). RESULTS:After the first PSMA, the MI group had a lower risk of all-cause mortality [hazard ratio (HR) 0.6; 95% confidence interval (95% CI) 0.5–0.8] compared with the non-MI group, but there was no significant difference in the incidence of CV events (HR 0.9; 95% CI 0.7–1.2). After the second PSMA, which additionally matched for PCI performance in the MI group, there were no differences in the risk of all-cause mortality (HR 1.0; 95% CI 0.7–1.5) or CV events (HR 1.1; 95% CI 0.8–1.5) between the MI and non-MI groups. CONCLUSIONS:There was no difference in all-cause mortality and CV events between patients with HFmrEF with and without MI. However, among patients with HFmrEF and MI, those who underwent PCI had a much lower risk of all-cause mortality compared with patients with HFmrEF without MI and with those with HFmrEF after MI who did not undergo PCI.