REVIEW article
Front. Cardiovasc. Med.
Sec. Cardiovascular Biologics and Regenerative Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1622248
This article is part of the Research TopicDeciphering Cardiovascular Cell Heterogeneity with Single Cell RNA SequencingView all 3 articles
tRNA-Derived Small RNAs (tsRNAs) in cardiovascular diseases: Biogenesis, Functions, and Therapeutic Targets
Provisionally accepted
- 1Nanchang University, Queen Mary School, Jiangxi Medical College, Nanchang, China
- 2Nanchang University, School of Pharmacy, Jiangxi Medical College, Nanchang, China
- 3Nanchang Univeristy, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang, China
- 4Nanchang University, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang, China
- 5Nanchang University, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang, China
- 6The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, China
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tRNA-derived small RNAs (tsRNAs) are a class of non-coding RNAs that are generated by cleavage of precursors or mature tRNAs under stress conditions such as hypoxia, oxidative stress and nutrient deficiency. Recent breakthroughs in RNA sequencing technology have revealed their association with cardiovascular diseases (CVDs), including myocardial infarction (MI), atherosclerosis, cardiac hypertrophy, aortic coarctation, and pulmonary arterial hypertension. tsRNAs play important biological functions in these diseases, including the inhibition of apoptosis, epigenetic modification, intercellular signaling mediation, translation, and regulation of gene expression. In addition, tsRNAs show promise as both detectable indicators and intervention targets for CVD. This review examines the biogenesis, classification, and multifaceted functions of tsRNAs in CVD, emphasizing their dual roles as diagnostic tools and therapeutic targets. Future research should focus on elucidating tsRNA-mediated regulatory networks and developing RNA-based interventions to address unmet needs in cardiovascular medicine.
Keywords: tRNA-derived small RNAs1, cardiovascular diseases (CVDs) 2, Biogenesis3, classification4, Therapeutic Targets5
Received: 22 May 2025; Accepted: 24 Jul 2025.
Copyright: © 2025 Xie, Chen, Wang, Si, Wang, Luo and Qi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qi Luo, Nanchang University, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang, China
Chan Qi, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, China
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