ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Structural Interventional Cardiology
Chronic kidney disease and survival following Indirect Mitral Annuloplasty for Functional Mitral Regurgitation
Provisionally accepted
Dennis Rottländer1,2*
Milad Golabkesh3Hubertus Degen3Dimitrios Barlagiannis3Alev Ögütcü3
Martin Saal3Michael Haude3- 1Krankenhaus Porz am Rhein, Cologne, Germany
- 2University Witten/Herdecke, Witten, Germany
- 3Rheinlandklinikum Neuss, Neuss, Germany
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Background: Chronic kidney disease is associated with poor prognosis following mitral valve edge-to-edge repair. We aimed to investigate the impact of chronic kidney disease (CKD) on survival in patients with functional mitral regurgitation (FMR) undergoing indirect mitral annuloplasty using the Carillon Mitral Contour System. Methods: In a retrospective analysis, a total of 100 consecutive FMR patients were assigned according to baseline renal function into three groups: estimated Glomerular Filtration Rate (eGFR) >60 ml/min/1.73m2, eGFR 30-59 ml/min/1.73m2 and eGFR<30 ml/min/1.73m2. At 3-and 12-months follow-up after indirect mitral annuloplasty survival, NYHA classification and transthoracic echocardiography were evaluated. Results: 30 patients revealed a baseline eGFR>60 ml/min/1.73m2 (30%), 51 an eGFR 30-59 ml/min/1.73m2 (51%) and 19 patients an eGFR <30 ml/min/1.73m2 (19%). 1-year mortality was significantly higher in eGFR 30-59 ml/min/1.73m2 and eGFR <30 ml/min/1.73m2 compared to a preserved renal function of eGFR>60 ml/min/1.73m2 (Log Rank test P value: 0.036). FMR patients with postprocedural acute kidney injury (AKI), defined as an increase in serum creatinine levels ≥0.3 mg/dl within 48 hours or ≥1.5 times baseline within 7 days post procedure, showed significantly increased mortality after indirect annuloplasty (Log Rank test P Value: 0.002). Carillon device implantation resulted in FMR reduction and improved NYHA classification at 3-and 12-months follow-up regardless of CKD. Conclusion: CKD in patients undergoing indirect mitral annuloplasty seems to be a negative predictor of outcome in FMR patients. However, Carillon device implantation improved NYHA and FMR classification regardless of renal function.
Keywords: transcatheter mitral valve repair, Functional mitral valve regurgitation, Carillon, Acute Kidney Injury, Chronic Kidney Disease
Received: 04 May 2025; Accepted: 18 Nov 2025.
Copyright: © 2025 Rottländer, Golabkesh, Degen, Barlagiannis, Ögütcü, Saal and Haude. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dennis Rottländer, dennis.rottlaender@uni-wh.de
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