REVIEW article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1627255
This article is part of the Research TopicUnraveling the Molecular Web of Inflammation and Fibrosis: Pathways, Immune Interactions, Epigenetics, and Therapeutic FrontiersView all 8 articles
Targeting inhibition of the inflammatory response: advances in the treatment of myocardial fibrosis with natural medicine and active ingredients
Provisionally accepted
- 1Gansu University of Chinese Medicine, Lanzhou, China
- 2Tianjin University of Traditional Chinese Medicine, Tianjin, China
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Myocardial fibrosis is a critical pathological foundation of cardiovascular diseases and a fundamental process underlying myocardial remodeling. The inflammatory response is a key driver of myocardial fibrosis, promoting the proliferation of myocardial fibroblasts and collagen deposition through the activation of multiple cytokines and signaling pathways. Natural medicines and active ingredients exhibit distinct therapeutic advantages characterized by not only potent pharmacological efficacy and favorable safety profiles, but also unique multi-target mechanisms of action that enable synergistic modulation of complex pathological pathways. These properties enable them to comprehensively modulate the inflammatory response, thereby providing novel therapeutic strategies for myocardial fibrosis. In this review, we explore the etiology of myocardial fibrosis and the mechanisms by which natural medicines and active ingredients inhibit the inflammatory response to treat myocardial fibrosis. We aim to provide a solid reference for future research on natural medicine-based therapies targeting the inflammatory pathways involved in myocardial fibrosis.
Keywords: Myocardial fibrosis, Inflammatory Response, Pathological mechanism, Natural medicine, Active ingredients
Received: 12 May 2025; Accepted: 24 Jul 2025.
Copyright: © 2025 Shu, Ren, Chen, Wang, Li, Zhang, Yang, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yingdong Li, Gansu University of Chinese Medicine, Lanzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.