CASE REPORT article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1627938
Case Report: Wolff-Chaikoff Effect-Induced Stabilization of Thyrotoxicosis in a Patient With Takotsubo Syndrome
Provisionally accepted
- The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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Takotsubo syndrome (TTS) is an acute stress-induced cardiomyopathy that mimics acute coronary syndrome. Although hyperthyroidism is a recognized trigger, it is often underappreciated in clinical practice.A 46-year-old woman with previously undiagnosed Graves' disease presented with TTS. Emergent coronary angiography was performed using iodinated contrast media (ICM). However, hepatic dysfunction initially delayed antithyroid drug administration. Unexpectedly, a marked decline in thyroid hormone levels occurred after ICM exposure, consistent with the Wolff-Chaikoff effect. The patient was stabilized with cardiac supportive care, dexamethasone, and lithium, followed by initiation of methimazole.
Keywords: Hyperthyroidism, Takotsubo syndrome, Iodine, Wolff-Chaikoff effect, Iodine-induced hyperthyroidism
Received: 13 May 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Fu, Wu, Li, He and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Juan Liu, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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