CASE REPORT article
Front. Cardiovasc. Med.
Sec. Hypertension
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1628754
Case report: A hybrid approach of selective adrenal artery and venous embolization for the treatment of unilateral aldosterone-producing adenoma
Provisionally accepted
- First Affiliated Hospital of Chengdu Medical College, Chengdu, China
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Selective adrenal artery embolization (SAAE) has emerged as a promising minimally invasive alternative to traditional therapies for primary aldosteronism (PA). However, incomplete ablation of aldosterone-producing adenomas (APA) tissue remains a key limitation. To address this challenge, we propose a novel hybrid approach integrating SAAE with selective adrenal venous embolization (SAVE), designed to optimize the therapeutic efficacy of APA. We report a 37-year-old man with confirmed unilateral PA. Left adrenal APA was diagnosed through computerized tomography and adrenal venous sampling. The patient underwent combined selective adrenal artery and venous embolization (SAAE-SAVE) for left-sided APA. Trans-catheter embolization of the dominant left adrenal artery and primary draining vein was performed using 2 mL anhydrous ethanol. This SAAE-SAVE protocol successfully normalized serum hypokalemia levels and achieved sustained blood pressure control at 1-month follow-up. SAAE-SAVE represents a transformative therapeutic alternative for APA treatment, and further research is needed to validate its safety and efficacy.
Keywords: Aldosterone-producing adenomas, adrenal artery embolization, Adrenal venous embolization, Adrenal arteriography, Adrenal venography
Received: 14 May 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Yang, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Peijian Wang, First Affiliated Hospital of Chengdu Medical College, Chengdu, China
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