REVIEW article
Front. Cardiovasc. Med.
Sec. Clinical and Translational Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1634059
Ultrasound-Targeted Microbubble Destruction: a prospective strategy for treating cardiovascular disease
Provisionally accepted
- 1Department of Ultrasound, affiliated hospital of Yunnan University, Kunming, China
- 2Department of Ultrasound, Second People’s Hospital of Yunnan Province, Kunming, China
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In China, the healthcare burden of cardiovascular diseases (CVDs) will continue to rise due to the pressure of the aging population, which has posed higher demands for CVDs prevention and treatment. Ultrasound-targeted microbubble destruction (UTMD) is an ultrasound-triggered drug delivery technique based on microbubbles. This technique utilizes the principles of cavitation and sonoporation to enhance the delivery of genes or drugs to target tissue. This review article will provide an overview of studies using UTMD to treat CVDs over the last decade. In light of these studies, we underscore the potential therapeutic targets and delineate the practical substances that can be loaded onto microbubbles. Additionally, a discussion is provided regarding the limitations and prospects of this field.
Keywords: cardiovascular disease, ultrasound, Microbubble, ultrasound targeted microbubble destruction (UTMD), Blood-brain barrier (BBB)
Received: 03 Jun 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Yang, Zhang and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Huali Zhang, Department of Ultrasound, affiliated hospital of Yunnan University, Kunming, China
Yongping Lu, Department of Ultrasound, affiliated hospital of Yunnan University, Kunming, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.