ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Heart Valve Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1635587
This article is part of the Research TopicFuture of Heart Valve Surgery: Enhancing Outcomes with Innovative TechnologiesView all articles
Short-term Outcomes of Repair versus Replacement for Rheumatic Mitral Valve Disease
Provisionally accepted
- 1Affiliated Hospital of North Sichuan Medical College, Nanchong, China
- 2Dazhou Third People's Hospital, Dazhuo, China
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Background: The main types of surgery for rheumatic mitral valve disease are traditional Percutaneous Mitral Balloon Valvuloplasty (PMBV), mitral valve replacement (MVR) with removal of the original valve, and valve repair with preservation of the original valve. Some studies have shown that mitral valve repair (MVr) has certain advantages compared with replacement. Methods: The clinical data of 166 patients with rheumatic mitral valve lesions admitted to the Department of Cardiac Macrovascular Surgery of the Affiliated Hospital of North Sichuan Medical College and the Dazhou Third People's Hospital were retrospectively analyzed to compare the hemodynamic changes after mitral valve repair and replacement. Results: 1. Hemodynamic evaluation of MVr:①Left Ventricular End-Diastolic diameters (LVEDD), Left Atrial End-Systolic Diameters (LAESD), Mitral E-wave velocity, Left Ventricular Ejection Fraction (LVEF), Mitral Valve Orifice Area (MVOA), Mitral Pressure Halving Time (PHT) and Mean Pressure Gradient (MPG) at each time point after MVr were improved compared with preoperative values (P<0.05). ②There was a significant improvement in the level of mitral regurgitation in MVr patients intraoperatively and at the time of discharge compared with preoperatively (P<0.05). 2. Hemodynamic evaluation of MVr and MVR:①Patients who underwent MVr had significantly lower LVEDD, LAESD, and mitral E-wave velocity than those who underwent MVR at each postoperative time point (P < 0.05). ②Patients who underwent MVr had lower Left Ventricular Posterior Wall thickness at end-diastole (LVPWd) than those who underwent MVR at 3 and 6 months postoperatively (P<0.05). ③Patients who underwent MVr had lower LVEF than those who underwent MVR at 6 months postoperatively (P<0.05). ④Patients who underwent MVr had lower Left Ventricular End-Diastolic Volume (LVEDV) than those who underwent MVR at 3 months postoperatively (P<0.05). Conclusions: Mitral valve repair and mitral valve replacement are effective in the treatment of patients with rheumatic mitral valve disease, with greater hemodynamic improvement after mitral valve repair than replacement, and with greater short-term clinical efficacy than valve replacement.
Keywords: Rheumatic mitral valve disease, Mitral valve repair, Mitral valve replacement, Hemodynamics, clinical efficacy
Received: 26 May 2025; Accepted: 24 Jul 2025.
Copyright: © 2025 Ming, Zhou and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ning Zhang, Dazhou Third People's Hospital, Dazhuo, China
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