ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Surgery
This article is part of the Research TopicSurgical Treatment and Perioperative Organ Protection for Coronary Heart Disease and Comorbid Chronic DiseasesView all 9 articles
Impact of Sarcopenia on Ventricular Remodelling Following Coronary Artery Bypass Grafting in Elderly Patients with Coronary Heart Disease
Provisionally accepted
- 1The First hospital of Hebei Medical University, Shijiazhuang, China
- 2Hebei Medical University, Shijiazhuang, China
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Objective: To investigate the association between sarcopenia and ventricular remodelling after coronary artery bypass grafting (CABG) in elderly patients with coronary heart disease (CHD). Methods: A total of 135 elderly patients with CHD admitted to hospital between February 2021 and May 2023 were prospectively selected. According to whether ventricular remodelling occurred during the follow-up period, patients were divided into an occurrence group and a non-occurrence group. Results: The incidence of ventricular remodelling after CABG in elderly patients with CHD was 23.70% (32/135). Significant differences between the two groups were observed in smoking history, diabetes history, prevalence of sarcopenia, degree of preoperative coronary stenosis, levels of lipoprotein (a) ([Lp(a)]), uric acid (UA), protease-activated receptor 2 (PAR2), monocyte-to-HDL ratio (MHR), and suspended red blood cell input (P < 0.05). Multivariable logistic regression analysis identified smoking history (odds ratio [OR] = 2.186, 95% confidence interval [CI] 1.34–3.57), diabetes history (OR = 2.171, 95% CI 1.32–3.58), sarcopenia (OR = 2.230, 95% CI 1.37–3.62), a high degree of preoperative coronary stenosis (OR = 2.223, 95% CI 1.36–3.64), elevated Lp(a) (OR = 2.143, 95% CI 1.32–3.49), elevated UA (OR = 2.164, 95% CI 1.31–3.58), elevated PAR2 (OR = 2.192, 95% CI 1.32–3.64), and elevated MHR (OR = 2.201, 95% CI 1.32–3.68) as independent risk factors for ventricular remodelling after CABG in the study population. Analysis showed that sarcopenia predicted ventricular remodelling with a sensitivity of 90.0%, specificity of 47.0%, and an area under the curve of 0.772 (95% CI 0.68–0.86, P < 0.0001). Conclusion: Sarcopenia is a risk factor affecting ventricular remodelling after CABG in elderly patients and shows strong predictive efficacy in this population.
Keywords: coronary heart disease, elderly patients, coronary artery bypass grafting, Left ventricular remodelling, Sarcopenia
Received: 27 May 2025; Accepted: 21 Nov 2025.
Copyright: © 2025 Li, Ma, Li, Su and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhenyu Su, hhzhengyu@outlook.com
Xugang Wang, wangxugang9@163.com
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