MINI REVIEW article
Front. Cardiovasc. Med.
Sec. Cardiovascular Metabolism
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1638515
Isoform-Specific Roles of AMP-Activated Protein Kinase (AMPK) in Cardiac Physiology and Pathophysiology
Provisionally accepted
- New York Institute of Technology, Old Westbury, United States
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AMP-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis, integrating metabolic, mitochondrial, and oxidative stress responses. In the heart, an organ with high and dynamically fluctuating energy demands, AMPK is essential for maintaining metabolic balance, particularly during conditions such as exercise, ischemia, hypertrophy, and heart failure. The AMPK complex comprises a catalytic α subunit and regulatory β and γ subunits, each with multiple isoforms (α1, α2; β1, β2; γ1, γ2, γ3) that confer tissue-specific distribution and functional specialization. This review highlights the isoform-specific roles of AMPK in the heart, emphasizing their distinct contributions to myocardial energy metabolism, contractile function, and cardiac remodeling across diverse physiological and pathological conditions.
Keywords: AMPK, isoform-specific, Energy Metabolism, Mitochondria quality control, cardiac remodeling
Received: 30 May 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Rakoubian, Khinchin, Yarbro, Kobayashi and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiangrong Liang, New York Institute of Technology, Old Westbury, United States
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