ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1639213
This article is part of the Research TopicOutcome-Oriented Approaches to Arrhythmia and Heart Failure TreatmentView all 14 articles
The Effect of Guideline-Directed Medicine on patients with new-onset heart failure following acute myocardial infarction
Provisionally accepted
Mengjie Lei1Jingyao Wang1Xiao Wang1Xue Sue1Cairong Li1Yanli Yang1Yachao Li1Zhigang Zhao1
Zengming Xue1,2*- 1Langfang People's Hospital Hebei, Langfang, China
- 2The Peoples Hospital of Langfang City, Langfang, China
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Aims To investigate the impact of guideline-directed medical therapy (GDMT) during hospitalization on the prognosis of patients with heart failure(HF) episode complicating post-acute myocardial infarction (AMI). Methods From 01/05/2017 to 30/09/2022, 527 patients with HF episode complicating post-AMI at a single medical center who were retrospectively analyzed. Based on whether GDMT during hospitalization was used in patients undergoing percutaneous coronary intervention (PCI), the patients were divided into the GDMT group (n=379) and the non-GDMT group (n=148), with a follow-up period of 12 months after PCI. The primary endpoint was the composite endpoint of all-cause death and all-cause readmission. Results The incidence of the primary endpoints (7.9% vs. 18.9%, P<0.001), cardiac death and cardiac readmission composite events (5.5% vs. 15.5%, P=0.002), all-cause readmission events (7.1% vs. 18.9%, P<0.001), and cardiac readmission events (5.0% vs. 13.5%, P=0.001) in the GDMT group were lower. Cox regression analysis revealed that the incidence of primary endpoints, cardiac death and cardiac readmission composite events, all-cause readmission events, and cardiac readmission events in patients treated with GDMT during hospitalization were 0.266 times (HR 0.266; 95% CI 0.146-0.487; P<0.001), 0.282 times (HR 0.282; 95% CI 0.137-0.581; P=0.001), 0.251 times (HR 0.251; 95% CI 0.136-0.464; P<0.001) and 0.262 times (HR 0.262; 95% CI 0.125-0.551; P<0.001), respectively, compared to patients treated without GDMT. Conclusion For patients with HF episode complicating post-AMI who undergo PCI, the use of GDMT during hospitalization reduces the incidence of primary endpoints, cardiac death and cardiac readmission composite endpoints, and all-cause readmission and cardiac readmission.
Keywords: Guideline-directed medical therapy, acute myocardial infarction, New-onset heart failure, prognosis, Percutaneous Coronary Intervention
Received: 01 Jun 2025; Accepted: 02 Sep 2025.
Copyright: © 2025 Lei, Wang, Wang, Sue, Li, Yang, Li, Zhao and Xue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zengming Xue, The Peoples Hospital of Langfang City, Langfang, China
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