ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1640707
Analysis of the correlation between EAT thickness and prognosis in patients with heart failure with preserved ejection fraction
Provisionally accepted
- Cangzhou Central Hospital, Cangzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Purpose: To explore the correlation between EAT thickness and prognosis in patients with heart failure with preserved ejection fraction. Method: 156 patients diagnosed with HFpEF were selected as the observation group. Another 150 healthy persons undergoing physical examination were selected as the control group. According to the 1-year follow-up results of prognosis of HFpEF patients, they were further divided into a good prognosis group (112 cases) and a poor prognosis group (46 cases). Result: The EAT thickness, LVMI, LAD, and LVEDD of HFpEF patients in the observation group were higher than those of the control group, and their LVEF was lower than that of the control group. EAT thickness was negatively correlated with LVEF, and EAT thickness was positively correlated with LVMI, LAD, and LVEDD. Hemoglobin and eGFR of the poor prognosis group were lower than those of the good prognosis group. The EAT thickness, blood lactate, and Scr in the poor prognosis group were higher than those in the good prognosis group. Reduced hemoglobin, increased EAT thickness, and increased blood lactate were risk factors for poor prognosis in patients with HFpEF. The receiver operating characteristic analysis showed that the optimal EAT cutoff value was 5.65 mm (AUC = 0.892, 95% CI = 0.833-0.936), with 89.13% sensitivity and 88.39% specificity. For the Kaplan–Meier survival analysis, when performing the post hoc stratification of event-free survival, we applied a clinician-relevant threshold of 7.59 mm. Conclusion: EAT thickness is inversely related to HFpEF severity and reflects left ventricular remodeling. EAT thickness may be a potentially useful non-invasive prognostic indicator of poorer outcomes in patients with HFpEF.
Keywords: EAT thickness, heart failure with preserved ejection fraction, prognosis, Risk factors, Heart Failure
Received: 04 Jun 2025; Accepted: 07 Aug 2025.
Copyright: © 2025 Ma, Zhang, Ma and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianfei Ma, Cangzhou Central Hospital, Cangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.