SYSTEMATIC REVIEW article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1641635
This article is part of the Research TopicNew Insights into the Pathogenesis, Diagnosis and Therapy of Chronic Heart Failure in Nonischemic CardiomyopathiesView all 6 articles
Effects of high-intensity interval training on inflammatory biomarkers in patients with heart failure: a meta-analysis of randomized controlled trials
Provisionally accepted
- 1Shanghai University of Sport, Shanghai, China
- 2The University of Texas Health Science Center at Houston School of Public Health, Houston, United States
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Background: There is still controversy about the effect of high-intensity interval training(HIIT) on the levels of cardiac and inflammatory biomarkers in patients with heart failure compared with moderate-intensity continuous training(MCT) and conventional healthcare activities. This article is to systematically investigate the effects of HIIT on the levels of cardiac and inflammatory biomarkers in patients with heart failure compared with MCT and conventional healthcare activities. Methods: A computerized search of databases was conducted with the search year from the establishment of the database, and the screened results were subjected to quality assessment and data extraction, and the data was meta-analyzed using RevMan 5.4.1 software. Results: 11 randomized controlled trials (RCTs) were finally included (7 RCTs about BNP and NT-proBNP, 2 RCTs about inflammatory factors, and 2 RCTs involve both), containing a total of 904 study subjects, 457 in the observation group, and 447 in the control group. Meta-analysis showed that HIIT significantly reduced BNP and NT-proBNP levels in patients with heart failure compared with the control group (SMD=-1.33, 95% CI: -2.55 ~ -0.11, P=0.03), while it had no significant effect on the level of CRP (SMD=-0.08, 95% CI: -0.33 ~ 0.18, P=0.56), TNF-α (MD=-0.11, 95% CI: -0.29 ~ 0.08, P=0.26), and IL-6 (MD=0.3, 95% CI: -1.95 ~ 2.55, P=0.8). Conclusions: Compared with MCT and conventional healthcare activities, the implementation of HIIT in patients with heart failure can effectively reduce the levels of heart failure biomarkers and improve their health. However, the difference between HIIT and the control group was not significant in the regulation of inflammatory factors.
Keywords: High-Intensity Interval Training1, Heart Failure2, Cardiac rehabilitation3, Inflammatory biomarkers4, Meta-analysis5
Received: 05 Jun 2025; Accepted: 01 Oct 2025.
Copyright: © 2025 Zhang, Hwang, Lu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xin Xu, xuxin@sus.edu.cn
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