ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Thrombosis and Haemostasis
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1641886
This article is part of the Research TopicAdvancements in Understanding and Managing Pulmonary Thromboembolism and HypertensionView all 4 articles
The effect of different treatment strategies on the right heart dysfunction during follow-up in the patients with acute pulmonary thromboembolism of intermediate-risk
Provisionally accepted
- 1The First Hospital of Jilin University, Changchun, China
- 2Jilin, Changchun, China
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Background:Acute pulmonary embolism (APE) is a disease with a high incidence and mortality rate. Currently, the preferred treatment methods for low - risk and high - risk of APE have been clearly defined, but there is still controversy regarding the optimal treatment for the intermediate - risk of APE.Patients with intermediate-risk APE have a relatively high thrombus burden, which can cause right heart function impairment during the follow-up period. It is still uncertain whether reperfusion therapy has an impact on right heart function during the follow-up period. Objectives: This study aims to evaluate the impact of reperfusion therapy on right heart function during the follow-up period in intermediate-risk APE patients by comparing the effects of different treatment strategies on right heart dysfunction (RHD) at 3 months. Methods:This study retrospectively included 216 patients who met the inclusion and exclusion criteria of this study. According to the treatment methods used, the patients were divided into the thrombolysis group, the catheter-directed thrombectomy group and the anticoagulation group. Results:In this study, the median follow - up time was 4.2 (3.1, 5.4) months.Among the patients with intermediate-risk APE ,the incidence of RHD in the catheter-directed thrombectomy group was lower than that in the anticoagulation group (P < 0.05). Among the patients with intermediate-high-risk APE,the incidence of RHD events after 3 months in both the thrombolysis group and the catheter-directed thrombectomy group was lower than that in the anticoagulation group (P < 0.05). Catheter-directed thrombectomy reduced the probability of RHD at 3 months to 0.12 of that with anticoagulation therapy alone (OR=0.12，95% CI: 0.015 - 0.994, P = 0.049). Conclusion:In patients with intermediate-risk APE, reperfusion therapy may reduce the occurrence of RHD impairment events after 3 months and improve the prognosis of patients. Key words: Acute pulmonary embolism, Pulmonary artery thrombus aspiration, Anticoagulation therapy, Thrombolysis therapy, Right heart dysfunction,Catheter-directed thrombectomy
Keywords: Acute pulmonary embolism, Pulmonary artery thrombus aspiration, Anticoagulation therapy, Thrombolysis therapy, Right heart dysfunction, Catheter-directed thrombectomy
Received: 05 Jun 2025; Accepted: 26 Aug 2025.
Copyright: © 2025 Wang, Li, Rong, Lu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weihua Zhang, Jilin, Changchun, China
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