CLINICAL TRIAL article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1643542
This article is part of the Research TopicCoronary Physiology in the Spotlight: Advancing Diagnosis and Treatment in CAD and Microvascular DiseaseView all 7 articles
A study on the correlation between the mean platelet volume to monocyte count ratio and long-term prognosis in patients with primary coronary artery disease
Provisionally accepted
Wei Fu1,2
Honghou He2
Jianan Xu2Peihong Wu2Qian Zhang2Mei Wei2Linan Duan2Gang Wang2Le Wang2
Zelong Cao2*
Mingqi Zheng2*- 1Hebei Medical University, Shijiazhuang, China
- 2Department of Cardiology, The First hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
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Coronary heart disease (CHD) arises from various mechanisms. In inflammatory cells, mean platelet volume (MPV) and monocyte count are integral to the atherosclerotic process and support the advancement of coronary heart disease. This study introduces a novel index, the mean platelet volume to monocyte count ratio (MMR). We utilized Cox proportional hazard modeling and restricted cubic spline (RCS) analysis to evaluate the connection between MMR values and major adverse cardiovascular events (MACE). In addition, we performed an AUC curve analysis to determine whether MMR would enhance the predictive model of MACE. The study observed the non-linear relationship between MMR levels and outcomes was clearly illustrated through a RCS plot, MACE associated with primary CHD showed a significant correlation, with a p-value of 0.001. In a multifactorial regression model, MMR level emerged as an independent risk factor for MACE, exhibiting a hazard ratio (HR) of 1.766, and a p-value of 0.002. The addition of MMR levels to the traditional predictive MACE model also resulted in a significant increase in the area under the ROC curve with p-value of 0.029. MMR levels were significantly associated with long-term cardiovascular risk, displaying an inverted U-shaped relationship. Further investigation is necessary to elucidate the mechanism underlying the relationship between MMR levels and long-term prognosis.Keywords：Mean platelet volume, Monocyte count, Cardiovascular risk, Major adverse cardiovascular events, the mean platelet volume/monocyte ratio.
Keywords: mean platelet volume, Monocyte count, cardiovascular risk, Major adverse cardiovascular events, the mean platelet volume/monocyte ratio.
Received: 09 Jun 2025; Accepted: 16 Sep 2025.
Copyright: © 2025 Fu, He, Xu, Wu, Zhang, Wei, Duan, Wang, Wang, Cao and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zelong Cao, caozelong@hebmu.edu.cn
Mingqi Zheng, mzheng@hebmu.edu.cn
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