CASE REPORT article
Front. Cardiovasc. Med.
Sec. Cardio-Oncology
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1643805
This article is part of the Research TopicCase Reports in Cardio-Oncology: 2025View all 7 articles
A Case Report of hepatocarcinoma-originated pericardial malignancy
Provisionally accepted
- Department of Cardiology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Cardiac tumors constitute an exceptionally rare neoplastic entity posing significant diagnostic challenges. We report a 55-year-old female patient without prior oncologic history who presented with acute-onset bilateral lower extremity edema progressing over 72 hours. Transthoracic echocardiography demonstrated a pericardial mass with concomitant hemorrhagic pericardial effusion. Subsequent magnetic resonance imaging and systemic positron emission tomography localized the lesion to the right bottom of the heart. Surgical exploration suggested a cardiac occupancy as an irregular, fish-flesh-like soft tissue mass, pathology biopsy was performed suggesting a malignant tumour of epithelial origin, and immunohistochemistry was suggestive of hepatic origin. The patient received combination therapy comprising programmed death-1 inhibitor camrelizumab (200 mg via intravenous infusion every 21 days) and oral lenvatinib (8 mg once daily). Serial contrast-enhanced computed tomography of the thorax and abdomen demonstrated progressive metastatic dissemination with malignant pleural and peritoneal effusion formation. Despite therapeutic intervention, the patient ultimately experienced disease progression culminating in mortality.
Keywords: Hepatocellular Carcinoma, Cardiac metastases, Diagnostic imaging - methods, Lenvatinib, camrelizumab
Received: 09 Jun 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Wu, Wang, Lin, Jian and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bin Wu, Department of Cardiology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Zhixiao Wang, Department of Cardiology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.