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CASE REPORT article

Front. Cardiovasc. Med.

Sec. Cardiac Rhythmology

Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1643915

This article is part of the Research TopicPast, Present, and Future of Brugada Syndrome: A Comprehensive FrameworkView all 3 articles

Brugada syndrome diagnosed in a young woman occurring postpartum: case report and literature review

Provisionally accepted
Wenhui  LiWenhui LiXiaoyu  PanXiaoyu PanJiaoying  ChengJiaoying Cheng*
  • China-Japan Friendship Hospital, Beijing, China

The final, formatted version of the article will be published soon.

Brugada syndrome (BrS), a hereditary cardiac channelopathy linked to malignant arrhythmias and sudden cardiac death, exhibits significant gender disparity with higher prevalence in males. This case report details a rare occurrence of BrS in a 32-year-old primigravida who suffered an acute cardiopulmonary arrest two hours postpartum. The patient, with no prior cardiac history or family history of sudden death, underwent an uncomplicated delivery but developed sudden pulselessness post-transfer to the ward. Immediate resuscitation and subsequent evaluations revealed a type I Brugada ECG pattern, while structural cardiac abnormalities, electrolyte imbalances, and other etiologies were excluded. Although genetic testing was negative for pathogenic variants, the clinical diagnosis of BrS was made. An implantable cardioverter-defibrillator (ICD) was implanted for secondary prevention. This case underscores the importance of recognizing BrS in atypical populations, advocating for heightened vigilance in postpartum women with unexplained cardiac events. Further research into female-specific risk factors and collaborative care frameworks is essential to optimize maternal and neonatal outcomes.

Keywords: Brugada Syndrome, Pregnancy, delivery, Perinatal management, case report

Received: 09 Jun 2025; Accepted: 22 Sep 2025.

Copyright: © 2025 Li, Pan and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Jiaoying Cheng, cjy19781031@163.com

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