ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1648215
This article is part of the Research TopicNew Perspectives on Drug-coated Balloons (DCB) For Treatment of Acute and Chronic Coronary Artery DiseaseView all articles
Efficacy and Safety of Drug-Coated Balloon Angioplasty in Proximal LAD Stenosis with Distal Myocardial Bridge: A 12-Month Comparative Study with Drug-Eluting Stents
Provisionally accepted
- Xiangtan Central Hospital, Xiangtan, China
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This retrospective single-center study evaluated the safety and efficacy of drug-coated balloon (DCB) angioplasty compared to drug-eluting stents (DES) in patients with proximal left anterior descending (LAD) artery stenosis accompanied by distal myocardial bridge (MB). A total of 231 patients were enrolled, with 83 undergoing DCB and 148 receiving DES treatment. All participants underwent coronary angiography and intravascular ultrasound to guide intervention. Over a 12-month follow-up period, DCB therapy was associated with significantly lower late lumen loss, target lesion restenosis (3.6% vs. 13.5%, p = 0.029), and major adverse cardiovascular events (MACE) (9.6% vs. 21.6%, p = 0.033) compared to DES. Although DES achieved greater acute lumen gain, both groups demonstrated comparable minimum lumen diameters and residual stenosis at follow-up. Multivariate analysis identified late lumen loss as an independent predictor of MACE. Notably, short-duration dual antiplatelet therapy in the DCB group was well tolerated, with low rates of thrombotic and bleeding events. These findings suggest that DCB angioplasty may be a safe and effective alternative to DES in anatomically complex LAD lesions with distal MB, offering superior vessel preservation and reduced long-term complications.
Keywords: Drug-coated balloon, Drug-eluting stent, Myocardial bridge, Percutaneous Coronary Intervention, Left anterior descending
Received: 16 Jun 2025; Accepted: 10 Jul 2025.
Copyright: © 2025 Wu, Wu, Huang, Liu, Huang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lei Wang, Xiangtan Central Hospital, Xiangtan, China
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