REVIEW article
Front. Cardiovasc. Med.
Sec. Cardiovascular Metabolism
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1656113
Ceramide Metabolism and Cardiovascular Risk Factors: Insights into Therapeutic Strategies
Provisionally accepted
守一 杨1
yongxin wu2*- 1Kunming University of Science and Technology, Kunming, China
- 2The First People's Hospital of Yunnan Province, Kunming, China
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Ceramides are components of sphingolipid metabolism and have been linked to cardiovascular disease (CVD) risk factors, including hypertension, insulin resistance, dyslipidemia and chronic kidney disease. Ceramide expression has been extensively studied but individual variability, species differences and regulatory mechanisms characterizing underlying relationships remain unclear. The current review analyzes roles of ceramides in the onset and progression of CVD and its risk factors. Diverse ceramide expression profiles are highlighted and recommendations for standardization of ceramide studies given.Ceramides are multifunctional and contribute to organ damage through dysregulated homeostasis during pathological processes.The current work emphasizes the importance of detecting ceramide imbalance and accounting for individual differences as a novel approach to metabolic research. Such a focus may enhance CVD management and give insights into ceramide-related pathologies.
Keywords: cardiovascular risk factors, Ceramides, Hypertension, Diabetes Mellitus, Dyslipidemia, Chronic Kidney Disease
Received: 30 Jun 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 杨 and wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: yongxin wu, The First People's Hospital of Yunnan Province, Kunming, China
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