REVIEW article
Front. Cardiovasc. Med.
Sec. Hypertension
Maximizing blood pressure lowering effects: A review of drug class comparisons and rationale for combination approaches
Provisionally accepted
- 1Chinese Academy of Medical Sciences and Peking Union Medical College Fuwai Hospital, Beijing, China
- 2Guangzhou Medical University Affiliated Eighth Hospital, Guangzhou, China
- 3University-Town Hospital of Chongqing Medical University, Chongqing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Numerous studies have reported on the antihypertensive effects of pharmacological treatments, primarily focusing on efficacy comparisons between drug classes, blood pressure (BP)-lowering responses in specific populations, or pleiotropic effects beyond BP reduction. However, the magnitude of BP reduction across agents varies.Additionally, the synergistic effects of combination therapies, and the potential existence of dose-response relationships remain significant clinical dilemmas for physicians. Emerging evidence suggests that many cardiovascular drugs exhibit incidental BP-lowering properties, though further validation is required. Given the critical role of BP management in cardiovascular care coupled with pharmacological heterogeneity and interpatient variability, clinicians face challenges in optimizing targeted treatment strategies for maximal therapeutic benefit. This review synthesizes current evidence on: (1) Drug-class-specific BP-lowering profiles, (2) Dose-dependent efficacy, and (3) Combination therapy strategies. The goal is to provide outcome-driven guidance for clinical decision-making in hypertension management.
Keywords: Antihypertensive Agents, blood pressure-lowering efficacy, dose-dependent efficacy, combination therapy, Hypertension
Received: 30 Jun 2025; Accepted: 13 Nov 2025.
Copyright: © 2025 Yang, Wan B#, Xu, Mei Deng and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pei Pan, 800398@hospital.cqmu.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.