CASE REPORT article
Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1656890
This article is part of the Research TopicCase Reports in Coronary Artery Disease: 2025View all 15 articles
Primary Antiphospholipid Syndrome Complicated by Recurrent Acute ST-Elevation Myocardial Infarction: A Case Report
Provisionally accepted
- Department of Cardiology, Peking University People's Hospital, Beijing, China
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Clinical management of primary antiphospholipid syndrome (PAPS) complicated by acute myocardial infarction (AMI) is particularly challenging, especially when recurrent AMI and thrombocytopenia are present. This case report describes a 35-year-old male patient with PAPS who experienced two episodes of acute inferior ST-elevation myocardial infarction (STEMI). Comprehensive diagnostic evaluations including coronary imaging, physiology, immunology, bone marrow morphology, and molecular biology were performed to confirm the diagnosis. A personalized treatment regimen combining clopidogrel, low-molecular-weight heparin, methylprednisolone, hydroxychloroquine, and rituximab was administered, which resulted in a favorable long-term prognosis. This case underscores the importance of a multidisciplinary approach and individualized treatment strategies based on coronary functional assessment for managing patients with PAPS and AMI.
Keywords: Acute ST-elevation myocardial infarction, Antiphospholipid Syndrome, Coronary physiology, Coronary microvascular dysfunction, Immunomodulation
Received: 30 Jun 2025; Accepted: 09 Oct 2025.
Copyright: © 2025 Huo, Hou, Cao, Peng and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jian Liu, drjianliu@163.com
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