ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Surgery
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1659336
Risk Factors of Prolonged Mechanical Ventilation After Acute Type A Aortic Dissection Surgery: A Single-Center Retrospective Study
Provisionally accepted
- 1Guangdong Provincial People's Hospital, Guangzhou, China
- 2Qiqihar Medical University, Qiqihar, China
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Objective: To identify the risk factors of prolonged mechanical ventilation after acute type A aortic dissection (ATAAD) surgery. Methods: 466 patients undergoing ATAAD surgery from 2016.01 to 2021.01were studied retrospectively. Risk factors of delayed extubation (>48 hours of ventilation) were identified using univariate and multivariate logistic regression. LASSO regression was used for variable selection. The ICU stay, hospital stay, complications, and 30-day mortality were analyzed. Results: Among the patients, 72% experienced delayed extubation. Risk factors included age (OR 1.042, 95% CI 1.005–1.083, P=0.031), postoperative serum creatinine (Scr, OR 1.006, 95% CI 1.003–1.010, P<0.001), and acute lung injury (ALI, OR 5.725, 95% CI 2.777–12.148, P<0.001). Delayed extubation was associated with increased ICU stays, hospital stays, and complications, including MODS and higher mortality. Conclusions: Age, postoperative serum creatinine, and acute lung injury are significant risk factors for prolonged ventilation. Early identification and management of these factors may improve postoperative outcomes.
Keywords: Extubation, Acute type A aortic dissection, Risk factors, Delay, Mortality
Received: 03 Jul 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Chen, Li, Lin, Su, Ling, Li and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guanying Chen, chenguanying2011@163.com
Chengbin Zhou, zcbwwww@163.com
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