ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Epidemiology and Prevention
This article is part of the Research TopicAdvancing Vascular Health: A Comprehensive Framework for Non-Traditional Risk AssessmentView all 7 articles
Value of Lipoprotein(a) in Predicting Severity of Coronary Artery Stenosis in Patients With Chronic Coronary Artery Disease: A Cross-Sectional Study in Vietnam
Provisionally accepted
Hao Thai Phan1*
Mai Thi Tuyet Ho2- 1Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam
- 2Tam Anh Hospital, Ho Chi Minh City, Vietnam
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Abstract Introduction: Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide. Lipoprotein (a) [Lp(a)] has emerged as an independent risk factor for CAD, but its role in predicting coronary severity in Vietnamese populations remains unclear. Objectives: To evaluate the value of Lp(a) in predicting the severity of coronary artery stenosis in chronic CAD. Materials and Methods: This cross-sectional study was conducted at Tam Anh General Hospital from June 2024 to June 2025, including 138 patients diagnosed with chronic CAD. Demographic, clinical, laboratory, and coronary angiographic data were collected. CAD severity was assessed using the Gensini score. Logistic regression and ROC analysis were employed to evaluate the predicting value of Lp(a). Results: Severe CAD (Gensini score> 40) was present in 31.9% of the cohort. Patients with Lp(a) ≥ 30 mg/dL exhibited a significantly higher prevalence of severe CAD (72.5% vs 8.0%). Lp(a) levels correlated strongly with the Gensini score. The optimal cut-off for predicting severe CAD was 30.6 mg/dL (AUC = 0.869). Multivariate analysis confirmed Lp(a) as an independent predictor. Conclusions: Lp(a) ≥30 mg/dL is strongly associated with severe coronary artery stenosis. Lp(a) is a valuable independent predictor of CAD severity and may serve as an essential tool for risk stratification in clinical practice.
Keywords: Lipoprotein (a) [Lp (a)], Gensini coronary score, Predicting, Coronary artery diasease, Coronary Stenosis
Received: 19 Jul 2025; Accepted: 28 Oct 2025.
Copyright: © 2025 Phan and Ho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hao Thai Phan, phanthaihao@yahoo.com
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