ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiovascular Surgery
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1671628
This article is part of the Research TopicRevolutionizing Aortic Repair: Advanced Surgical and Endovascular Techniques for Comprehensive Aortic Management from the Aortic Valve to the Abdominal AortaView all 3 articles
Can Computational Fluid Dynamics Simulations Predict a Distal Stent Graft-Induced New Entry after Frozen Elephant Trunk Operation?
Provisionally accepted
Anja Osswald1*
Konstantinos Tsagakis1
Matthias Thielmann1Sharaf-Eldin Shehada1Rolf Alexander Jánosi1
Payam Akhyari1
Christof Karmonik2- 1University of Duisburg-Essen, Duisburg, Germany
- 2Houston Methodist Research Institute, Houston, United States
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Objectives: Distal stent graft-induced new entry (dSINE) is a complication after frozen elephant trunk (FET) procedure. The purpose of this study was to identify the hemodynamic profile of the aorta associated with dSINE development using computational fluid dynamics (CFD) simulation. Methods: 30 patients, 15 who had developed a dSINE (dSINE group) and 15 without any further vascular events (control group), undergoing an FET operation for aortic dissection were retrospectively included in this CFD study. Patient-specific 3D surface models of the aortic lumen were reconstructed from computed tomography angiographic (CTA) datasets, utilizing the CTA acquired before dSINE onset. Steady-state CFD simulations were performed with laminar blood flow and zero-pressure outlet conditions to assess velocity magnitudes, wall shear stress (WSS), and vorticity within the stent graft (SG), its distal landing zone and further downstream. Results: In the dSINE group, WSS was significantly elevated distal to the SG compared to WSS within the SG and at its landing (2.95 ± 1.47 Pa vs. 1.56 ± 0.71 Pa and 2.00 ± 0.81 Pa, p<0.001 for This is a provisional file, not the final typeset article both comparisons). In the control group, this distinct pattern of distal WSS elevated distal to the SG in comparison to other locations was not observed. Similarly, vorticity increased significantly distally to the SG in the dSINE group, but not in the control group. Conclusions: Increased WSS distal to the SG compared to within the SG and its landing zone seem to be associated with dSINE development. CFD can be a useful tool to understand SG-induced hemodynamic changes in the aorta to help predict complications after FET.
Keywords: Wall Shear Stress, Computational fluid dynamics simulation, Distal stent graft-induced new entry, Frozen elephant trunk, aortic dissection
Received: 23 Jul 2025; Accepted: 24 Sep 2025.
Copyright: © 2025 Osswald, Tsagakis, Thielmann, Shehada, Jánosi, Akhyari and Karmonik. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Anja Osswald, anja.osswald@uk-essen.de
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