ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Intensive Care Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1671841
Association of Preoperative Systemic Inflammation with Postoperative Conduction Block in TAVI Patients
Provisionally accepted
- 1The First Affiliated Hospital of Anhui Medical University, Hefei, China
- 2Anhui Medical University, Hefei, China
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Background: Conduction block (CB) is a frequent complication following transcatheter aortic valve implantation (TAVI). Systemic inflammation may play a role in its development, but evidence is limited. Methods: This prospective study included 155 patients who underwent TAVI. Preoperative systemic inflammation markers—including systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR)—were analyzed in relation to postoperative conduction block and cardiac function using logistic and linear regression models, as well as restricted cubic spline analysis. Results: Postoperative conduction block occurred in 35.5% of patients. Higher preoperative SII (OR = 1.0009; P = 0.0289), NLR (OR = 1.1630; P = 0.0253), and PLR (OR = 1.0079; P = 0.0065) were significantly associated with increased CB risk, while higher LMR was protective (OR = 0.7435; P = 0.0194). LMR was also independently associated with reduced ejection fraction and increased left ventricular volume. Gender subgroup analysis showed stronger associations in females. Conclusion: Preoperative systemic inflammation is independently associated with conduction block and cardiac function outcomes after TAVI. Inflammation-based biomarkers may serve as useful tools for risk stratification and perioperative planning.
Keywords: conduction block, systemic inflammation, Inflammatory biomarkers, Neutrophil-to-lymphocyte ratio, risk stratification
Received: 23 Jul 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Shi, Di, Zhang, Gong and Ge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sheng-Lin Ge, geshenglin2025@163.com
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