CASE REPORT article
Front. Cardiovasc. Med.
Sec. Structural Interventional Cardiology
Transcatheter Pulmonary Valve Replacement with the VenusP-Valve System in a Patient with Double Outlet Right Ventricle and Transposition of the Great Arteries A First-in-Human Case Report
Provisionally accepted
Federica Gramegna1
Paolo Denti2
Matteo Saccocci2*
Nicola Buzzatti2
alessandro faggi1
Eustachio Agricola1,2
Ottavio Alfieri2
Massimo Chessa3Francesco Maisano1,2- 1Universita Vita Salute San Raffaele, Milan, Italy
- 2San Raffaele Hospital (IRCCS), Milan, Italy
- 3IRCCS Policlinico San Donato, San Donato Milanese, Italy
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The Taussig-Bing anomaly is a rare form of double outlet right ventricle (DORV) characterized by complex physiology, often requiring multiple surgeries. This report describes the use of the VenusP-Valve System in a 36-year-old patient with Taussig-Bing anomaly, transposition of the great arteries (TGA), and prior surgical interventions including Blalock–Taussig shunt, arterial switch, and ventricular septal defect (VSD) closure. The patient presented with atrial fibrillation, baseline clinical signs of right-sided heart failure (jugular venous distension, edema, holosystolic murmur), New York Heart Association (NYHA) III symptoms, severe tricuspid regurgitation (TR), residual VSD, and significant pulmonary stenosis. Right-heart catheterization revealed an extremely high baseline Qp/Qs of 10.4, derived by the Fick method with oxygen consumption estimation and mixed venous sampling; this value was interpreted as artifact-influenced, and normalized to ~2 after medical optimization. After multidisciplinary discussion, a transcatheter pulmonary valve replacement (TPVR) using the VenusP-Valve System was successfully performed. At 30 days, the patient improved to NYHA II with no major complications, reduction of TR to moderate, and stable residual VSD shunt (Qp/Qs ~2). This case highlights the feasibility and clinical utility of VenusP-Valve in managing complex congenital heart disease, particularly in enlarged, irregular, patch-augmented right ventricular outflow tracts (RVOTs) not suitable for balloon-expandable or hourglass-anchoring valves.
Keywords: Pulmonary Valve, VenusP Valve, Double Outlet Right Ventricle, Transposition of the great arteries, transcatheter valve implantation
Received: 23 Jul 2025; Accepted: 14 Oct 2025.
Copyright: © 2025 Gramegna, Denti, Saccocci, Buzzatti, faggi, Agricola, Alfieri, Chessa and Maisano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Matteo Saccocci, dr.saccocci@gmail.com
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