ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Machine Learning-Based Prediction Model for 30-Day Readmission Risk in Elderly Patients with Type 2 Diabetes Mellitus and Heart Failure: A Retrospective Cohort Study with SHAP Interpretability Analysis
Provisionally accepted
- 1The Second Affiliated Hospital of Wannan Medical College, Wuhu, China
- 2Department of Pharmacy, The Second Affiliated Hospital of Wannan Medical College, Wuhu, China
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Objective: Among elderly populations with concurrent type 2 diabetes mellitus (T2DM) and heart failure (HF), 30-day hospital readmission rates range 10-25%. Conventional risk evaluation instruments show restricted predictive performance (AUC<0.70) in this multimorbid group. This research aimed to construct and verify an artificial intelligence-based algorithm for assessing 30-day readmission probability in elderly T2DM-HF patients. Methods: This retrospective cohort study included 870 participants ≥65 years with T2DM and HF (January 2020-December 2023), randomly divided into training (n=609, 70%) and validation (n=261, 30%) cohorts. Variable selection utilized Least Absolute Shrinkage and Selection Operator with ten-fold cross-validation. Eight machine learning algorithms were evaluated: logistic regression, random forest, gradient boosting machines, support vector machines, neural networks, convolutional neural networks, AdaBoost, and stacking ensemble. Model interpretability was enhanced using SHapley Additive exPlanations analysis. Results: Overall 30-day readmission rate was 12.4% (108/870 patients). The Stacking Ensemble model achieved superior performance with AUC 0.867 (95% CI: 0.830-0.904), accuracy 79.4%, sensitivity 74.9%, and specificity 84.0%. Fourteen key predictors were identified, with C-reactive protein, estimated glomerular filtration rate, and B-type natriuretic peptide as most influential factors. Conclusion: This study developed a high-performing, interpretable machine learning model for predicting 30-day readmission risk, providing a valuable clinical decision-making tool.
Keywords: type 2 diabetes mellitus, Heart Failure, 30-day readmission, machine learning, risk prediction
Received: 25 Jul 2025; Accepted: 20 Nov 2025.
Copyright: © 2025 Wang, Wei, Chen, Lu, Zhang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mo Yang, poiljn321@163.com
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