CASE REPORT article
Front. Cardiovasc. Med.
Sec. Heart Valve Disease
Fungal endocarditis complicating intracranial multifocal hemorrhages: a case report
Provisionally accepted
- 1Shaanxi Provincial Rehabilitation Hospital, Neurological Rehabilitation Department, Xi'an, China
- 2Xi'an Medical University, Xi'an, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Fungal endocarditis carries a high mortality rate, with intracranial multifocal hemorrhage representing a severe yet rarely reported complication. We present a case of a 60-year-old female with a history of rheumatic valvular disease who underwent bioprosthetic mitral valve replacement and developed fungal endocarditis with vegetation formation 12 years postoperatively. Following antifungal therapy, the patient underwent redo mitral valve replacement. The postoperative course was complicated by acute subdural hematoma, subarachnoid hemorrhage, and cerebral herniation, necessitating emergent burr hole drainage. Multidisciplinary management achieved hemodynamic stabilization, though with residual neurological deficits including hemiplegia and dysphagia.This case highlights the critical risk of fatal intracranial hemorrhage during the perioperative period of fungal endocarditis, underscoring the need for enhanced monitoring and proactive intervention. The clinical course provides valuable insights for managing such life-threatening complications.
Keywords: case report, fungal endocarditis, Mitral valve replacement, intracranial multifocal hemorrhage, Antifungal treatment
Received: 29 Jul 2025; Accepted: 17 Nov 2025.
Copyright: © 2025 Han, Huang, Li and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiuqi Liu, 526141828@qq.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.