REVIEW article
Front. Cardiovasc. Med.
Sec. Cardiovascular Metabolism
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1677684
This article is part of the Research TopicThe Role of Gut Microbiome Metabolites in Cardiometabolic DisordersView all 6 articles
Role of gut microbiota and its metabolites in diabetic cardiomyopathy: From pathogenesis to interventions
Provisionally accepted
- 1Shaoxing People's Hospital, Shaoxing, China
- 2Zhuji People's Hospital of Zhejiang Province, Zhuji, China
- 3Ningbo Medical Centre Lihuili Hospital Department of Cardiology, Ningbo, China
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Diabetic cardiomyopathy (DCM), a prevalent cardiovascular complication and the principal driver of mortality among patients with diabetes, represents a significant clinical challenge. The gut microbiota, which reside a complex ecosystem within the human intestinal tract, play a fundamental role in host metabolism and systemic physiology. Mounting evidence underscores a critical link between gut microbial dysbiosis, microbial-derived metabolites, and DCM pathogenesis mediated through the gut-heart axis. This comprehensive review systematically synthesizes the current research elucidating the multifaceted interplay between the gut microbiota, their bioactive metabolites (e.g., short-chain fatty acids, bile acids, and branched-chain amino acids), and the development and progression of DCM. By critically evaluating the mechanisms underlying the gut-heart crosstalk, we provide novel insights into the etiopathogenesis of DCM. Furthermore, we evaluated emerging therapeutic strategies aimed at mitigating DCM by targeted modulation of the gut microbiota and their metabolic output, highlighting promising avenues for future research and clinical translation.
Keywords: Diabetic cardiomyopathy, Gut Microbiota, Metabolites, short-chain fatty acids, gut-heart axis
Received: 01 Aug 2025; Accepted: 04 Sep 2025.
Copyright: © 2025 Ji, Yu, Gu, Wang, Meng, Lin and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Lin, Ningbo Medical Centre Lihuili Hospital Department of Cardiology, Ningbo, China
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