ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Clinical and Translational Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1677922
Association between the triglyceride-glucose index and the risk of Left ventricular aneurysm formation among patients with acute ST-segment elevation myocardial infarction
Provisionally accepted
- The Centre Hospital of Wuhan, Wuhan, China
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Abstract Background The triglyceride–glucose (TyG) index has been closely associated with a range of cardiovascular diseases. However, the association between the TyG index and left ventricular aneurysm (LVA) formation in patients with acute ST-segment elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI) remains unknown. Methods This study recruited 551 patients in the first cohort and 471 patients in the validation cohort. To determine the independent risk factors associated with LVA formation, a multivariable logistic regression analysis was conducted. The predictive capability of both the TyG index and the composite variable for LVA formation was evaluated through the use of ROC curve analysis. Results The prevalence of LVA was found to be 14.5% in the first cohort and 13.6% in the validation cohort. In both cohorts, a higher TyG index correlated with an increased incidence of LVA (20.5% vs. 8.0%, P< 0.001 in the first cohort; 18.4% vs. 8.6%, P= 0.002 in the validation cohort). The TyG index was consistently elevated in the LVA group in comparison to those without LVA (9.3±0.7 vs. 8.9±0.9, P< 0.001 in the first cohort; 9.4±0.7 vs. 9.0±0.7, P< 0.001 in the validation cohort). Analysis using multivariable logistic regression showed that an independent relationship exists between the TyG index and the risk of LVA in both the first (OR= 4.2, P= 0.004) and validation (OR= 2.11, P= 0.008) cohorts.
Keywords: Triglyceride-glucose index, Left ventricular aneurysm, Acute ST-segment elevation myocardial infarction, Primary percutaneous coronary intervention, risk prediction
Received: 01 Aug 2025; Accepted: 10 Oct 2025.
Copyright: © 2025 Hu, Zhao, Lin, Zhao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dong Hu, hudong202508@163.com
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