ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Clinical and Translational Cardiovascular Medicine
Associations of novel blood-derived markers of inflammation with blood pressure, arterial stiffness and heart rate in young adults
Provisionally accepted
- 1Flinders University, Adelaide, Australia
- 2Universita degli Studi di Sassari, Sassari, Italy
- 3The University of Western Australia Medical School, Perth, Australia
- 4Flinders Medical Centre, Bedford Park, Australia
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Background: Although C-reactive protein (CRP) is often used to assess inflammation and can predict high blood pressure (BP) and arterial stiffness, novel measures of inflammation derived from platelets, white blood cell counts, and high-density lipoprotein cholesterol (HDL-C) may also indicate possible hypertension and arterial stiffening. Methods. We assessed the association between CRP and novel inflammatory markers and clinical BP, arterial stiffness, and heart rate (HR) in Gen2 Raine Study participants in Western Australia aged 17–22 years. Arterial stiffness was assessed using pulse-wave velocity (PWV), augmentation index (AIx), and pulse pressure (PP). Inflammatory markers included high-sensitivity CRP (hsCRP); hsCRP-to-albumin ratio; lymphocyte, monocyte, neutrophil, and platelet counts; neutrophil-to-lymphocyte ratio (NLR); platelet-to-lymphocyte ratio (PLR); mean platelet volume; neutrophil percentage-to-albumin ratio; monocyte/HDL-C ratio; neutrophil/HDL-C ratio; Prognostic Nutritional Index and the Systemic Inflammation Index (SII). Results. Males (N=363) had higher systolic BP (SBP) (∆=9.1 mmHg, p<0.001), lower diastolic BP (DBP) (∆=-0.9 mmHg, p<0.001), and higher PWV (∆=0.37 m/sec; p<0.001) than females (N=330). The lymphocyte count, monocyte/HDL-C ratio, and neutrophil/HDL-C ratio were positively associated with SBP, PP, and AIx. The platelet count was positively associated with SBP, DBP, and PP. Most inflammatory indices were associated with HR, and associations with SBP, DBP, AIx, and PWV were stronger in males than in females. The hsCRP and SII levels were not associated with SBP, DBP, PP, AIx, or PWV. Conclusions. The lymphocyte count, monocyte/HDL-C ratio, neutrophil/HDL-C ratio, and platelet count showed more robust associations with blood pressure and arterial stiffness in young adults compared to hsCRP and SII, suggesting their potential utility in this specific context.
Keywords: Blood Pressure, arterial stiffness, C-Reactive Protein, markers of inflammation, platelets, HDL-Cholesterol, White blood cell counts
Received: 13 Aug 2025; Accepted: 07 Nov 2025.
Copyright: © 2025 Woodman, Zinellu, Mori, Beilin and Mangoni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Richard John Woodman, richard.woodman@flinders.edu.au
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