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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.

Sec. Cardiovascular Imaging

Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1688931

This article is part of the Research TopicRevolutionizing Cardiovascular Diagnosis: Advances in Functional Imaging TechnologiesView all 11 articles

Myocardial Work in Chagas Disease: Comparative Analysis with Conventional Parameters in Different Cardiac Clinical Stages

Provisionally accepted
Alex Dos Santos FelixAlex Dos Santos Felix1,2*Daniel KasalDaniel Kasal1Rodolfo De Paula LustosaRodolfo De Paula Lustosa1Marcelo Imbroinise BittencourtMarcelo Imbroinise Bittencourt2Pedro Pimenta de Mello SpinetiPedro Pimenta de Mello Spineti2Bruno Reznik WajsbrotBruno Reznik Wajsbrot2Marcia Bueno CastierMarcia Bueno Castier2Ricardo Mourilhe-RochaRicardo Mourilhe-Rocha2
  • 1Department of Research and Education, National Institute of Cardiology, Rio de Janeiro, Brazil
  • 2Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

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Chagas' disease (CD) is a neglected chronic infectious disease and represents an important cause of morbidity and mortality in endemic areas of Latin America. Chronic Chagas cardiomyopathy (CCC) is the most severe manifestation of the disease and the leading cause of death in these patients. Myocardial deformation, measured by speckle-tracking echocardiography (STE), has been proven to detect subclinical disease, even before regional wall motion abnormalities and global left ventricular (LV) dysfunction are detected, with recognized prognostic value in CCC, but it is load dependent. In this study, we analyzed Myocardial Work as a new index for the evaluation of Chagas disease patients in different stages of cardiac disease. Global work index (GWI) and Global constructive work (GCW) showed great correlation with left ventricular ejection fraction (LVEF), and the best accuracy to detect LV dysfunction, when compared to other echocardiographic parameters, including two-dimensional longitudinal strain.

Keywords: Chagas Cardiomyopathy, Heart Failure, myocardial work, cardiac imaging, Strain Echocardiography

Received: 19 Aug 2025; Accepted: 09 Oct 2025.

Copyright: © 2025 Felix, Kasal, Lustosa, Imbroinise Bittencourt, Spineti, Reznik Wajsbrot, Castier and Mourilhe-Rocha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Alex Dos Santos Felix, alexsfelix@gmail.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material