REVIEW article
Front. Cardiovasc. Med.
Sec. Cardiovascular Metabolism
This article is part of the Research TopicAdvancements in Understanding and Managing Residual Risk of Coronary Artery DiseasesView all 3 articles
The Advances of DEAD-box RNA helicase 17 in chronic non-infectious diseases
Provisionally accepted
- Western Theater General Hospital, Chengdu, China
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DEAD-box RNA helicase 17 (DDX17), a key member of the DEAD-box family, is vital in cellular physiological processes. This review summarizes its structural properties, distribution, functions, disease associations, and research trends. Structurally, DDX17 has a conserved DEAD-box domain with RNA-dependent ATPase and helicase activities, producing p72 and p82 isoforms. It distributes in the nucleus and cytoplasm, highly expressed in cardiomyocytes and neuronal tissues. Functionally, DDX17 regulates RNA metabolism, DNA repair, and protein interactions. It is linked to chronic non-infectious diseases: promoting tumor progression via pathways like Wnt/ β -catenin; protecting myocardial function in cardiovascular diseases; and involving in neurological disorders.This review provides insights for exploring its biological functions and clinical applications.
Keywords: Chronic non-infectious diseases, DDX17, Structure, function, tumors, Cardiovascular Diseases
Received: 24 Aug 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 Sun, Xiong, Wang, Wang, Li, Deng, Wang, Li and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiongshan Sun, shan19910927@sina.com
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