MINI REVIEW article
Front. Cardiovasc. Med.
Sec. Heart Valve Disease
This article is part of the Research TopicTranscatheter Valve Interventions in Heart Failure: Emerging Strategies and OutcomesView all articles
To clip or not to clip? A review of precise risk assessment in the contemporary era of transcatheter edge-to-edge mitral and tricuspid valve repair
Provisionally accepted
Felix Ausbuettel1*
Carlo-Federico Fichera2- 1Universitatsklinikum Giessen und Marburg - Standort Marburg, Marburg, Germany
- 2County Hospital Loerrach, Loerrach, Germany
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Transcatheter edge-to-edge mitral and tricuspid valve repair (M-TEER, T-TEER) have emerged as meaningful treatment modalities among patients at high surgical risk suffering from valvular heart disease. While previous research has shown that optimal patient selection is crucial for treatment outcomes, recent studies have identified a multitude of factors that independently influence mortality. Although these findings can significantly support clinical decision-making, the large number of available studies renders an overview of this topic challenging. In this review, we provide a comprehensive overview of the currently identified factors associated with increased mortality after TEER. We also summarize the current evidence on published risk scores that stratify mortality risk after M-TEER and T-TEER. We aimed to provide clinical decision-making support for optimal patient selection and referral to TEER and to identify remaining gaps in evidence.
Keywords: M-TEER, T-TEER, Mortality prediction, Transcatheter edge-to-edge repair, mitraclip, triclip, PASCAL
Received: 26 Aug 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Ausbuettel and Fichera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Felix Ausbuettel, felix@ausbuettel.info
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