REVIEW article
Front. Cardiovasc. Med.
Sec. General Cardiovascular Medicine
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1705201
Cardiovascular manifestations in mast cell activation disease: Key insights for cardiologists and angiologists
Provisionally accepted
Wolfgang Taumann1
Gerhard J. Molderings2*- 1Mast Cell Sciences Ltd., Meckenheim, Germany
- 2Institute of Human Genetics, University Hospital Bonn, Bonn, Germany
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Mast cell activation disease is a genetic disease entity characterized by a very pronounced clinical symptomatologywith potential manifestations in virtually every organ and tissue. These arise from the inappropriate release of mast cell mediators and the accumulation of both morphologically normal and mutated mast cells. Owing to the high prevalence of the disease - estimated to be up to 17% - cardiologists and angiologists are frequently confronted with mast cell activation disease in their daily clinical practice often without recognizing it. Therefore, every cardiologist and angiologist should possess basic knowledge about this disease and be aware of its cardiovascular challenges. This review summarizes the current state of knowledge on the the highly complex mast cell activation disease, with a particular focus on the cardiovascular aspects.
Keywords: Mast cell activation disease, systemic mastocytosis, Mast cell activation syndrome, mast cell mediator release syndrome, Mast cell mediators, Cardiovascular symptoms
Received: 14 Sep 2025; Accepted: 14 Oct 2025.
Copyright: © 2025 Taumann and Molderings. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gerhard J. Molderings, molderings@uni-bonn.de
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