CASE REPORT article
Front. Cardiovasc. Med.
Sec. Heart Valve Disease
This article is part of the Research TopicTranscatheter Valve Interventions in Heart Failure: Emerging Strategies and OutcomesView all 3 articles
Transcatheter Aortic Valve Replacement for Severe Aortic Regurgitation in Quadricuspid Aortic Valve: a case report
Provisionally accepted
- University of Maryland Medical Center, Baltimore, United States
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A 49-year-old woman with a congenital quadricuspid aortic valve presented in cardiogenic shock due to severe aortic regurgitation. She underwent transfemoral transcatheter aortic valve replacement with a 29 mm self-expanding prosthesis. The procedure was technically successful with minimal paravalvular leak and significant symptomatic improvement. However, her long-term course was complicated by medication nonadherence, valve thrombosis, thromboembolic coronary events, and progressive heart failure. This case highlights the anatomical and technical challenges of transcatheter valve therapy in non-tricuspid anatomy, including annular sizing and valve anchoring without calcification, and underscores the critical importance of post-procedural anticoagulation adherence and meticulous follow-up to prevent thrombotic complications.
Keywords: Quadricuspid aortic valve, TAVR, Aortic regurgitation, Transcatheter aortic valve replacement, valve thrombosis, thromboembolic coronary events
Received: 30 Sep 2025; Accepted: 25 Nov 2025.
Copyright: © 2025 Aljudaibi, Sonbol and Allaham. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Abdullah Aljudaibi
Mark Sonbol
Haytham Allaham
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