Frontiers in Cellular Neuroscience | Cellular Neuropathology

Specialty Grand Challenge

Published on 06 Jan 2026

Hot topics in Cellular Neuropathology IV—targeting neurological diseases by gene therapy approaches

in Cellular Neuropathology

Dirk M. Hermann

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1769815

473 views

Original Research

Accepted on 05 Jan 2026

Increased dendritic inhibition of dentate gyrus granule cells in a mouse model of Down syndrome

in Cellular Neuropathology

Nicole Gutmann
Ute Häussler
Anabel Mersi
Marie Follo
Josef Bischofberger
Jan M Schulz

Frontiers in Cellular Neuroscience

Original Research

Published on 02 Jan 2026

Trazodone modulates behavioral alterations in scopolamine-induced cognitive deficit by targeting brain-derived neurotropic factor and cAMP response element-binding protein signaling

in Cellular Neuropathology

Prashant Dhaka
Pinky
Neha
Mohammad Ahmad Khan
Syed Arman Rabbani
Mohamed El-Tanani
Suhel Parvez

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1681080

399 views

Review

Accepted on 29 Dec 2025

Local synthesis and function of neuro-estrogen and neuro-androgen: impact on the hippocampus-related cognition and neuronal plasticity

in Cellular Neuropathology

Suguru Kawato
Yasushi Hojo
Soma Mika
Shigeo Horie
Minoru Saito
Mari Ogiue-Ikeda

Frontiers in Cellular Neuroscience

116 views

Review

Accepted on 29 Dec 2025

Molecular and Developmental Insights into Proprioceptive Identity in the Mesencephalic Trigeminal Nucleus Neurons

in Cellular Neuropathology

Pa Reum Lee
Seog Bae Oh

Frontiers in Cellular Neuroscience

141 views

Original Research

Accepted on 23 Dec 2025

Intermittent fasting reduces glaucomatous damage in an HSP27 autoimmune mouse model

in Cellular Neuropathology

Dominik L. Maler
Sabrina Reinehr
Leonie Deppe
H. Burkhard Dick
Stephanie C Joachim

Frontiers in Cellular Neuroscience

192 views

Original Research

Accepted on 22 Dec 2025

Adult organotypic brain slice cultures recapitulate extracellular matrix remodelling in haemorrhagic stroke

in Cellular Neuropathology

Benjamin J. Hewitt
Lauren Roberts
James A. Roberts
Daniel Fulton
Lisa J Hill
Philip Kitchen
Roslyn Mary Bill
Hannah Botfield

Frontiers in Cellular Neuroscience

180 views

Original Research

Accepted on 22 Dec 2025

Neuronal differentiation and activity drive nucleocytoplasmic shuttling of the intellectual disability kinase TLK2

in Cellular Neuropathology

Lubna Nuhu-Soso
Heidi Denton
Darren L Goffin
Ines Hahn
Gareth J.O. Evans

Frontiers in Cellular Neuroscience

190 views

Editorial

Accepted on 18 Dec 2025

Editorial: Novel Approaches to Foster Brain Plasticity in Neurodevelopmental and Neurodegenerative Disorders

in Cellular Neuropathology

Anna Letizia Allegra Mascaro
Laura Baroncelli
Marco Cambiaghi

Frontiers in Cellular Neuroscience

161 views

Review

Published on 17 Dec 2025

Neural stem cells fate under neuroinflammatory conditions and oxidative stress response

in Cellular Neuropathology

Filippo Torrisi
Simona Denaro
Jenny Ragonese
Simona D’Aprile
Agata Zappalà
Rosalba Parenti

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1736865

600 views

Original Research

Published on 17 Dec 2025

Neurosteroid withdrawal disrupts GABAergic system development in human cortical organoids: implications for preterm birth

in Cellular Neuropathology

Helene Lacaille
Ekaterina Lebayle
Barbara Corneo
Claire-Marie Vacher
Anna A. Penn

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1715823

866 views

Brief Research Report

Published on 15 Dec 2025

Single-nucleus RNA-seq reveals no increase in T cells in Alzheimer’s disease prefrontal cortex or hippocampus

in Cellular Neuropathology

Jake D. Oxendine
Daniel W. Sirkis
Caroline Jonson
Jennifer S. Yokoyama

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1681881

1,007 views

Review

Accepted on 09 Dec 2025

Extracellular vesicles in Niemann Pick Disease Type C: Current knowledge and future opportunities

in Cellular Neuropathology

Sarah Catherine B Hawthorne
Ursula S Sandau
Julie A Saugstad

Frontiers in Cellular Neuroscience

186 views

Review

Published on 08 Dec 2025

Astrocytic and microglial cell functions in neuroinflammatory diseases and their animal models

in Cellular Neuropathology

Kei Hashimoto
Mari Gotoh
Hiroko Ikeshima-Kataoka

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1708775

1,004 views

Original Research

Published on 05 Dec 2025

Long-term low-dose aspirin promotes laser-induced choroidal neovascularization through suppressing TSP-1 expression

in Cellular Neuropathology

Caijiao Yi
Chang Luo
Jiawu Zhao
Christophe Roubeix
Judith Lechner
Rosana Penalva
Nan Yang
Jian Liu
Qichang Wang
Usha Chakravarthy

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1716229

1,000 views

Review

Published on 03 Dec 2025

Deciphering the role of tRNA-derived fragments in neurological and psychiatric disease pathogenesis

in Cellular Neuropathology

Huseyin Kocakusak
Aysu Başak Kök
Bilgesu Ozturk
Bilge Karacicek
Sermin Genc

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1663788

1,455 views

Original Research

Accepted on 25 Nov 2025

Glutamate load fosters spreading depolarization under osmotic stress in brain slices

in Cellular Neuropathology

Rita Frank
Stephane Marinesco
Ferenc Bari
Ákos Menyhárt
Eszter Farkas

Frontiers in Cellular Neuroscience

238 views

Perspective

Published on 25 Nov 2025

Fetal development and the air pollution exposome: an integrative perspective of health pathways

in Cellular Neuropathology

Eric Alonso Abarca-Castro
José Javier Reyes-Lagos
Kioko Guzmán Ramos
Augusto J. Montiel-Castro
Hypatia Arano-Varela
Pablo Adolfo Mayer-Villa
José Eleazar Aguilar-Toalá
José Luis Montesillo-Cedillo
Ana Karen Talavera-Peña

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1688437

1,249 views

Correction

Published on 24 Nov 2025

Correction: CRISPR-Cas9: bridging the gap between aging mechanisms and therapeutic advances in neurodegenerative disorders

in Cellular Neuropathology

Anas Shamsi
Mohammed Alrouji
Othman AlOmeir
Syed Tasqeruddin
Khuzin Dinislam
Azna Zuberi

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1739705

1,115 views

Mini Review

Published on 21 Nov 2025

Persistent pollutants and the developing brain: the role of PFAS in neurodevelopmental disorders

in Cellular Neuropathology

Laura Lagostena
Valeria Magnelli
Davide Rotondo
Francesco Dondero

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1696173

1,880 views

Correction

Published on 20 Nov 2025

Correction: The role of oxidative stress in spinal cord ischemia reperfusion injury: mechanisms and therapeutic implications

in Cellular Neuropathology

Yu Xing
Yuan-zhang Xiao
Min Zhao
Jiang-jun Zhou
Kai Zhao
Chun-lin Xiao

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1742278

664 views

Review

Published on 10 Nov 2025

Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration

in Cellular Neuropathology

Guang Yang
Xiao Xu
Waimao Gao
Xingyu Wang
Yan Zhao
Ying Xu

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1700692

2,047 views
2 citations

Review

Published on 07 Nov 2025

Microglial TREM2 and cognitive impairment: insights from Alzheimer’s disease with implications for spinal cord injury and AI-assisted therapeutics

in Cellular Neuropathology

Zhonghan Wu
Shuisheng Yu
Dasheng Tian
Li Cheng
Juehua Jing

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1705069

1,760 views

Original Research

Published on 03 Nov 2025

Neuroprotection of IGF-1 in neonatal hypoxic-ischemic brain injury through downregulation of FoXO3a-PUMA pathway

in Cellular Neuropathology

Yanli Tang
Rui Zhong
Jiayi Liang
Shuang Liu
Wanxia Liu
Tao Liu
Baohong Yuan
Mengya Jiao
Hui Yin

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1685800

1,079 views

2,054 articles

articles

Hot topics in Cellular Neuropathology IV—targeting neurological diseases by gene therapy approaches

Increased dendritic inhibition of dentate gyrus granule cells in a mouse model of Down syndrome

Trazodone modulates behavioral alterations in scopolamine-induced cognitive deficit by targeting brain-derived neurotropic factor and cAMP response element-binding protein signaling

Local synthesis and function of neuro-estrogen and neuro-androgen: impact on the hippocampus-related cognition and neuronal plasticity

Molecular and Developmental Insights into Proprioceptive Identity in the Mesencephalic Trigeminal Nucleus Neurons

Intermittent fasting reduces glaucomatous damage in an HSP27 autoimmune mouse model

Adult organotypic brain slice cultures recapitulate extracellular matrix remodelling in haemorrhagic stroke

Neuronal differentiation and activity drive nucleocytoplasmic shuttling of the intellectual disability kinase TLK2

Editorial: Novel Approaches to Foster Brain Plasticity in Neurodevelopmental and Neurodegenerative Disorders

Neural stem cells fate under neuroinflammatory conditions and oxidative stress response

Neurosteroid withdrawal disrupts GABAergic system development in human cortical organoids: implications for preterm birth

Single-nucleus RNA-seq reveals no increase in T cells in Alzheimer’s disease prefrontal cortex or hippocampus

Extracellular vesicles in Niemann Pick Disease Type C: Current knowledge and future opportunities

Astrocytic and microglial cell functions in neuroinflammatory diseases and their animal models

Long-term low-dose aspirin promotes laser-induced choroidal neovascularization through suppressing TSP-1 expression

Deciphering the role of tRNA-derived fragments in neurological and psychiatric disease pathogenesis

Glutamate load fosters spreading depolarization under osmotic stress in brain slices

Fetal development and the air pollution exposome: an integrative perspective of health pathways

Correction: CRISPR-Cas9: bridging the gap between aging mechanisms and therapeutic advances in neurodegenerative disorders

Persistent pollutants and the developing brain: the role of PFAS in neurodevelopmental disorders

Correction: The role of oxidative stress in spinal cord ischemia reperfusion injury: mechanisms and therapeutic implications

Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration

Microglial TREM2 and cognitive impairment: insights from Alzheimer’s disease with implications for spinal cord injury and AI-assisted therapeutics

Neuroprotection of IGF-1 in neonatal hypoxic-ischemic brain injury through downregulation of FoXO3a-PUMA pathway