MINI REVIEW article
Front. Dement.
Sec. Translational Research in Dementia
Volume 4 - 2025 | doi: 10.3389/frdem.2025.1605051
This article is part of the Research TopicStudying Dementia in 3D: Basic Techniques and ApplicationsView all articles
Psychedelics Meet Human Brain Organoids: Insights into Proteomics and Potential for Alzheimer's Disease Treatment
Provisionally accepted
- School of Medicine, Johns Hopkins University, Baltimore, United States
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Alzheimer's disease (AD) is characterized by a long preclinical phase lasting more than a decade before the onset of its clinical phase of Mild Cognitive Impairment (MCI) or dementia. Recent advances in psychedelic research underscore numerous neuroplastogenic and anti-inflammatory alterations induced by these compounds, making them promising therapeutic candidates for AD. In this mini-review, we will briefly summarize the existing literature using human cerebral organoids to study the molecular and metabolic changes caused by various psychedelic compounds, focusing on their potential therapeutic applications for AD.
Keywords: Alzheimer's disease (AD), brain organoids, psychedelics, Stem Cells, neuroplasticity
Received: 02 Apr 2025; Accepted: 01 Jul 2025.
Copyright: © 2025 Androni, Boyd, Rosenberg and Machairaki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Vasiliki Machairaki, School of Medicine, Johns Hopkins University, Baltimore, United States
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