Frontiers in Dementia | Cellular and Molecular Mechanisms of Dementia

Hypothesis and Theory

Published on 24 Jun 2026

Hierarchical-circular model of biological memory: a multilevel hypothesis for pathogenesis and allostatic integrity in Alzheimer’s disease and related dementias

in Cellular and Molecular Mechanisms of Dementia

Samuel Ruesga Mundo

Frontiers in Dementia

doi 10.3389/frdem.2026.1841647

1,154 views
1 citation

Review

Published on 03 Jun 2026

Post-translational modifications as a regulatory code for tau function in health and disease

in Cellular and Molecular Mechanisms of Dementia

Abigail J. Nordbeck
Bhirisha Sharma
Charles A. Garcia
Jui-Heng Tseng

Frontiers in Dementia

doi 10.3389/frdem.2026.1834737

2,054 views
2 citations

Original Research

Published on 06 Mar 2026

Amyloid-β acute exposition affects the CA1 hippocampal network activity and its topological organization, evaluated with multielectrode arrays

in Cellular and Molecular Mechanisms of Dementia

David Alcantara-Gonzalez
Elizabeth Santiago
Fernando Peña-Ortega

Frontiers in Dementia

doi 10.3389/frdem.2026.1738954

1,953 views

Mini Review

Published on 09 Dec 2025

BACE1 at the crossroads of a vicious circle between Alzheimer’s disease and diabetes mellitus

in Cellular and Molecular Mechanisms of Dementia

Masuo Ohno

Frontiers in Dementia

doi 10.3389/frdem.2025.1730524

3,767 views
3 citations

Review

Published on 17 Jun 2025

Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer’s disease

in Cellular and Molecular Mechanisms of Dementia

Helen E. Scharfman
Korey Kam
Áine M. Duffy
John J. LaFrancois
Paige Leary
Elissavet Chartampila
Stephen D. Ginsberg
Christos Panagiotis Lisgaras

Frontiers in Dementia

doi 10.3389/frdem.2025.1513144

5,307 views
2 citations

Original Research

Published on 16 Apr 2025

Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease

in Cellular and Molecular Mechanisms of Dementia

Zachery D. Morrissey
Pavan Kumar
Trongha X. Phan
Mark Maienschein-Cline
Alex Leow
Orly Lazarov

Frontiers in Dementia

doi 10.3389/frdem.2025.1546433

5,407 views
2 citations

Original Research

Published on 28 Oct 2024

Quantitative proteomic analysis using a mouse model of Lewy body dementia induced by α-synuclein preformed fibrils injection

in Cellular and Molecular Mechanisms of Dementia

Fatih Akkentli
In kyu Jang
Yoonseop Choi
Young Min
Jinhee Park
Heejin Jo
Leoni Kim
Aashi Mendpara
Bikram Bains
Dongyoon Yoo

Frontiers in Dementia

doi 10.3389/frdem.2024.1477986

4,653 views
3 citations

Original Research

Published on 17 Jun 2024

Evidence for prodromal changes in neuronal excitability and neuroinflammation in the hippocampus in young alpha-synuclein (A30P) transgenic mice

in Cellular and Molecular Mechanisms of Dementia

Ibtisam Al-Musawi
Bethany H. Dennis
Gavin J. Clowry
Fiona E. N. LeBeau

Frontiers in Dementia

doi 10.3389/frdem.2024.1404841

4,730 views
4 citations

Opinion

Published on 06 Jul 2023

SARS-CoV-2 amyloid, is COVID-19-exacerbated dementia an amyloid disorder in the making?

in Cellular and Molecular Mechanisms of Dementia

Nathaniel G. N. Milton

Frontiers in Dementia

doi 10.3389/frdem.2023.1233340

9,053 views
9 citations

Review

Published on 15 Jun 2023

Hearing loss and its link to cognitive impairment and dementia

in Cellular and Molecular Mechanisms of Dementia

Abdul Azeem
Arun Julleekeea
Beth Knight
Isha Sohail
Michael Bruyns-Haylett
Magdalena Sastre

Frontiers in Dementia

doi 10.3389/frdem.2023.1199319

27,614 views
40 citations

Mini Review

Published on 18 Apr 2023

Accelerated long-term forgetting: A sensitive paradigm for detecting subtle cognitive impairment and evaluating BACE1 inhibitor efficacy in preclinical Alzheimer's disease

in Cellular and Molecular Mechanisms of Dementia

Masuo Ohno

Frontiers in Dementia

doi 10.3389/frdem.2023.1161875

4,488 views
10 citations

Review

Published on 12 Apr 2023

The emerging role of the HTRA1 protease in brain microvascular disease

in Cellular and Molecular Mechanisms of Dementia

Christof Haffner

Frontiers in Dementia

doi 10.3389/frdem.2023.1146055

6,638 views
8 citations

Original Research

Published on 12 Sep 2022

The effect of Aβ seeding is dependent on the presence of knock-in genes in the AppNL−G−F mice

in Cellular and Molecular Mechanisms of Dementia

Sean G. Lacoursiere
Jiri Safar
David Westaway
Majid H. Mohajerani
Robert J. Sutherland

Frontiers in Dementia

doi 10.3389/frdem.2022.941879

3,831 views
4 citations

13 articles

articles

Hierarchical-circular model of biological memory: a multilevel hypothesis for pathogenesis and allostatic integrity in Alzheimer’s disease and related dementias

Post-translational modifications as a regulatory code for tau function in health and disease

Amyloid-β acute exposition affects the CA1 hippocampal network activity and its topological organization, evaluated with multielectrode arrays

BACE1 at the crossroads of a vicious circle between Alzheimer’s disease and diabetes mellitus

Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer’s disease

Neurogenesis drives hippocampal formation-wide spatial transcription alterations in health and Alzheimer's disease

Quantitative proteomic analysis using a mouse model of Lewy body dementia induced by α-synuclein preformed fibrils injection

Evidence for prodromal changes in neuronal excitability and neuroinflammation in the hippocampus in young alpha-synuclein (A30P) transgenic mice

SARS-CoV-2 amyloid, is COVID-19-exacerbated dementia an amyloid disorder in the making?

Hearing loss and its link to cognitive impairment and dementia

Accelerated long-term forgetting: A sensitive paradigm for detecting subtle cognitive impairment and evaluating BACE1 inhibitor efficacy in preclinical Alzheimer's disease

The emerging role of the HTRA1 protease in brain microvascular disease

The effect of Aβ seeding is dependent on the presence of knock-in genes in the AppNL−G−F mice