SYSTEMATIC REVIEW article
Front. Dent. Med.
Sec. Systems Integration
Volume 6 - 2025 | doi: 10.3389/fdmed.2025.1581738
This article is part of the Research TopicAdvances in Multi-Omics and Imaging for Precision DentistryView all articles
ADVANCING PRECISION DENTISTRY: THE INTEGRATION OF MULTI-OMICS AND CUTTING-EDGE IMAGING TECHNOLOGIES – A SYSTEMATIC REVIEW
Provisionally accepted
- Sri Sai College of Dental Surgery, Vikarabad, Telangana, Hyderabad, India
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The convergence of multi-omics, advanced imaging technologies, and artificial intelligence (AI) is reshaping diagnostic strategies in precision dentistry. This systematic review critically assesses how the integration of multi-omics (genomics, proteomics, metabolomics), advanced imaging modalities (CBCT, MRI), and AI-based techniques synergistically enhances diagnostic accuracy, clinical decision-making, and personalized care in dentistry.The review follows PRISMA 2020 guidelines. A total of 50 studies published between 2015 and 2024 were selected using a PICOS framework. Analytical tools included meta-analysis (Forest and Funnel plots), risk of bias assessment, VOS viewer-based bibliometric mapping, and GRADE evidence grading.Multi-omics approaches revealed key biomarkers such as TP53, IL-1, and MMPs in early diagnosis. CBCT reduced diagnostic error by 35% (CI: 30-40%), while MRI improved soft-tissue evaluation by 25% (CI: 18-32%). AI tools, including convolutional neural networks and radiomics, led to a 40% reduction in diagnostic time (CI: 33-45%) and improved lesion classification.Integrating AI with omics and imaging technologies enhances diagnostic precision in dentistry. Future efforts must address data standardization, ethical implementation, and validation through multicenter trials for clinical adoption. 1. PubMed: Focused on medical and biological literature, particularly studies on multi-omics, imaging, and clinical dentistry.2. Scopus: Provided access to interdisciplinary research on artificial intelligence (AI), imaging technologies, and oral health.3. Web of Science: Offered robust coverage of diverse research fields, including clinical trials, AI integration, and multi-omics studies.4. Embase: Specialized in pharmacological and biomedical literature, particularly emphasizing multi-omics research.
Keywords: Precision dentistry1, Multi-omics2, proteomics3, PRISMA4, AI in dentistry5, CBCT6, MRI7
Received: 23 Feb 2025; Accepted: 26 May 2025.
Copyright: © 2025 Das. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Neelam Das, Sri Sai College of Dental Surgery, Vikarabad, Telangana, Hyderabad, India
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