SYSTEMATIC REVIEW article
Front. Dent. Med.
Sec. Dental Materials
Volume 6 - 2025 | doi: 10.3389/fdmed.2025.1602738
This article is part of the Research TopicExpanding Knowledge on Mineralized Tissues in Dental Science: Enamel, Dentin, and Pulp TissueView all 3 articles
The histological and radiological evaluation of the autologous peripheral venous blood concentrates (APVBCs) in socket preservation:a systematic review and meta-analysis
Provisionally accepted
- Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China
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Objectives: A detailed meta-analysis and systematic search was conducted to assess the histologic and radiographic efficacy of the autologous peripheral venous blood concentrates (APVBCs) for the socket preservation. Design: Electronic databases were searched until January 31, 2025, randomized controlled trials (RCTs) and controlled clinical trials(CCTs) in English were identified. The alveolar bone reconstruction by the histologic and radiographic evaluation after teeth extraction. Data were analyzed by Revman5.3, and the risk of bias was evaluated using the Cochrane Collaboration tool. Results: 16 studies(12 RCTs and 4 CCTs) involving 619 sites were included in our meta-analysis, the results indicated that the APVBCs application significantly reduced the vertical bone resorption in the buccal ridge (SMD: -0.30; 95%CI: -0.54 to-0.06, p=0.02, I²=5%) and palatal/lingual ridge (SMD:-0.30, 95%CI:-0.54 to-0.06, p=0.02, I² =0%) by the radiographic analysis. Additionally, the vertical resorption of the buccal and palatal/lingual alveolar ridge was significantly reduced by using materials combined with APVBCs as the filling material for extraction sockets. The newly formed bone percentage was showed a statistically significant increase in the APVBCs presence during socket preservation(SMD: 1.27, 95%CI: 0.65 to 1.89, P<0.0001, I ² =71%) and APVBCs+ materials groups(SMD: 0.85, 95% CI: 0.35 to 1.35, P=0.0009, I ² = 0%). However, APVBCs+ materials did not show significant effects on the remaining graft particles. Conclusions: The APVBCs in socket preservation can reduce the vertical bone resorption and enhance the newly bone formation. Meanwhile, APVBCs may improve the osteogenic efficiency with bone graft material.
Keywords: the autologous peripheral venous blood concentrates, Platelet rich plasma, Platelet rich fibrin, concentrated growth factor, Socket preservation
Received: 30 Mar 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 MENG, Wu, Wang, Yang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yusheng MENG, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China
Yun Liu, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China
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